某三甲肿瘤专科医院2016—2019年1455例药品不良反应报告分析

Analysis of 1455 Reports of Adverse Reactions in A Grade Three Class A Cancer Hospital from 2016 to 2019

目的总结并分析中国科学院大学附属肿瘤医院(浙江省肿瘤医院)2016—2019年上报的药品不良反应(ADR),为临床合理安全用药提供参考。方法对1455例ADR发生与患者原患疾病、性别、年龄、药品种类、给药途径、ADR累及系统/器官和临床表现、报告人职业、ADR类型、关联性评价、转归等进行回顾性分析。结果1455例ADR报告中,原患疾病最多的为肺恶性肿瘤;77.46%的关联性评价为很可能;61~70岁年龄段ADR构成比最高,占36.36%;主要涉及抗肿瘤药物、镇痛药、肠内肠外营养制剂、抗菌药物;静脉滴注给药引起ADR最多;引起血液系统、消化系统ADR最多;ADR主要由药师上报;绝大部分ADR治疗后好转,未出现死亡病例。结论ADR发生与患者原患疾病、年龄、给药途径、累及系统/器官和临床表现等因素具有相关性。加强ADR监测,提高医护人员对ADR的认知和上报意识,可以减少ADR的发生,为患者提供安全、经济、有效的治疗。

Objective To provide references for rational drug use,the adverse reactions(ADR)reported from 2016 to 2019 in Cancer Hospital of The University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)were summarized and analyzed.Methods A total of 1455 ADR reports were retrospectively collected and analyzed in terms of original diseases,gender,age,drug type,route of administration,system/organ involved in ADR,manifestation,reporter occupations,ADR type,relevance evaluation,outcome,and so on.Results Among 1455 ADR reports,the most common disease was lung malignant tumors,and 77.46%of the correlations were rated as very likely.The elderly patients aged from 61-70 years were accounted for the highest composition ratio(36.36%).The drugs that caused ADR were antitumor drugs,analgesic,intracenteral and parenteral nutrition preparations,antimicrobial agents.The intravenous administration was the main route of administration causing ADR;and blood system and digestive system were involved frequently.Adverse drug reactions were mainly reported by pharmacists;and most of the adverse reactions were improved after treatment,and there were no deaths.Conclusion The occurrence of adverse drug reactions was related to factors such as the patients’original diseases,age,route of administration,system/organ involved in ADR,reporter occupations.Strengthening the monitoring of adverse drug reactions,improving the awareness and reporting of adverse drug reactions in medical staff may reduce the occurrence of adverse drug reactions and provide safe,economical and effective treatment for patients.