肝癌介入治疗中应用栓塞微球的治疗效果及其不良反应观察

Therapeutic Effect and Side Effects of Embolization Microspheres in Interventional Therapy of Liver Cancer

目的:观察肝癌介入治疗中应用栓塞微球的治疗效果及其不良反应发生情况。方法:选取2019年1月-2020年6月于本院治疗的肝癌患者80例,依据治疗方案的差异分为两组,每组40例。对照组采用碘化油栓塞治疗,研究组采用微球联合碘化油栓塞治疗。比较两组临床疗效、肝功能水平、不良反应发生情况及肿瘤标志物水平。结果:研究组治疗有效率为75.0%,高于对照组的47.5%,差异有统计学意义(P<0.05)。干预前,两组AST、ALT、CA12-5、CEA、CA19-9水平比较,差异均无统计学意义(P>0.05)。干预后2个月,两组AST、ALT水平均较干预前下降,且研究组上述指标水平均低于对照组,差异均有统计学意义(P<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。干预后1个月,两组CA12-5、CEA、CA19-9水平均较干预前下降,且研究组上述指标均低于对照组,差异均有统计学意义(P<0.05)。结论:对接受肝癌介入治疗的患者采用栓塞微球干预,可有效提升临床治疗效果,改善患者肝功能水平,降低肿瘤标志物表达水平,且不会增加不良反应发生,值得借鉴。

Objective:To observe the therapeutic effect and adverse reactions of embolization microspheres in interventional therapy of liver cancer.Method:A total of 80 liver cancer patients treated in our hospital from January 2019 to June 2020 were selected and divided into two groups according to the difference of treatment regimen,40 cases in each group.The control group was treated with Iodized Oil embolization,and the study group was treated with Microspheres combined with Iodized Oil embolization.Clinical efficacy,liver function level,incidence of adverse reactions and tumor marker level were compared between the two groups.Result:The effective rate in the study group was 75.0%,higher than 47.5%in the control group,the difference was statistically significant(P<0.05).Before intervention,there were no significant differences in AST,ALT,CA12-5,CEA and CA19-9 levels between 2 groups(P>0.05).2 months after intervention,AST and ALT levels in both groups were lower than those before intervention,and the levels of the above indicators in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).1 month after intervention,the levels of CA12-5,CEA and CA19-9 in both groups were lower than those before intervention,and the above indexes in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Embolization microsphere intervention for patients receiving liver cancer interventional therapy can effectively improve the clinical treatment effect,improve the liver function level of patients,reduce the expression level of tumor markers,and do not increase the occurrence of adverse reactions,which is worth learning.