苏合香丸联合血塞通注射液治疗急性脑梗死的效果及对血液流变学指标、氧化应激反应水平的影响

Effect of Suhexiang Pills Combined with Xuesaitong Injection in the Treatment of Acute Cerebral Infarction and Its Influence on Hemorheological Indexes and Oxidative Stress Levels

目的:探讨苏合香丸联合血塞通注射液治疗急性脑梗死的效果及对血液流变学指标、氧化应激反应水平的影响。方法:选取2019年1月-2021年1月本院收治的160例急性脑梗死患者,随机分为对照组和研究组,每组80例。对照组给予苏合香丸治疗,研究组在对照组基础上给予血塞通注射液治疗。比较两组治疗前后血液流变学指标、炎性因子水平、生活质量评分、氧化应激反应水平。结果:两组治疗前血液流变学指标对比,差异均无统计学意义(P>0.05);研究组治疗后血浆黏度、血小板聚集率、血细胞比容、纤维原蛋白均低于对照组(P<0.05)。两组治疗前炎性因子水平比较,差异均无统计学意义(P>0.05);研究组治疗后炎性因子水平均低于对照组(P<0.05)。治疗前,两组的生活质量评分比较,差异均无统计学意义(P>0.05);治疗后,两组生活质量评分均明显高于治疗前,且研究组均高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组氧化应激反应指标比较,差异均无统计学意义(P>0.05);治疗后,两组氧化应激反应指标均优于治疗前,且研究组SOD高于对照组,ROS、MDA均低于对照组,差异均有统计学意义(P<0.05)。结论:对急性脑梗死患者采用苏合香丸联合血塞通注射液治疗,效果理想,可改善应激反应指标,且生活质量水平明显提升,是一种安全且有效的治疗方法,因此值得广泛应用。

Objective:To explore the effect of Suhexiang Pills combined with Xuesaitong Injection in the treatment of acute cerebral infarction and its influence on hemorheology indexes and oxidative stress levels.Method:A total of 160 patients with acute cerebral infarction admitted to our hospital from January 2019 to January 2021 were randomly divided into the control group and the study group,with 80 cases in each group.The control group was given Suhexiang Pills,and the study group was given Xuesaitong Injection on the basis of the control group.The hemorheology indexes,inflammatory factor levels,quality of life scores,and oxidative stress response levels were compared between the two groups before and after treatment.Result:There were no significant differences in hemorheological indexes between two groups before treatment(P>0.05);after treatment,the plasma viscosity,platelet aggregation rate,hematocrit and fibrinogen in the study group after treatment were lower than those in the control group(P<0.05).There were no statistically significant differences in the levels of inflammatory factors between two groups before treatment(P>0.05);after treatment,the levels of inflammatory factors in the study group were lower than those in the control group(P<0.05).There were no statistically significant differences in the quality of life scores between two groups before treatment(P>0.05);after treatment,the quality of life scores of the two groups were significantly higher than those before treatment,and the study group were higher than those of the control group,the differences were statistically significant significance(P<0.05).Before treatment,there were no statistically significant difference in oxidative stress response indexes between two groups(P>0.05);after treatment,the oxidative stress response indexes of two groups were better than those before treatment,and SOD of the study group was higher than that of the control group,ROS and MDA were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion:Suhexiang Pills combined with Xuesaitong Injection for patients with acute cerebral infarction has an ideal effect,can improve the stress response index,and the quality of life is significantly improved,it is a safe and effective treatment method,so it is worthy of wide application.