cGAS-cGAMP-STING通路在抗病毒中的作用

Role of cGAS-cGAMP-STING pathway in antivirus

先天性免疫是宿主防御病原体入侵机体的第一道防线。胞质中异常核酸的检测表明一些保守的病原相关分子模式(pathogen associated molecular patterns)引发了Ⅰ型干扰素(IFN)介导的先天性免疫反应。DNA传感器环鸟苷酸-腺苷酸合成酶(cGAS)识别并结合宿主或病原体胞质DNA,促使第二信使环鸟苷酸-腺苷酸(cGAMP)的合成并触发干扰素基因刺激蛋白(STING)依赖性下游信号传导。该文简述了cGAS-cGAMP-STING通路及其在抗病毒研究中的最新进展,为开展病毒防治研究提供新思路,为抗病毒药物的研发提供新的方向。

Innate immunity is the host's first line defense against pathogens invading to the body.Detection of abnormal nucleic acids in the cytoplasm showed that some conserved pathogen associated molecular patterns(PAMPS)triggered type I interferon(IFN)-mediated innate immune responses.The DNA sensor—cGAS(cGAMP Synthase)recognizes and binds to host or pathogen cytoplasmic DNA,promotes the formation of the second messenger cGAMP(cyclic GMP-AMP),and triggers STING(stimulator of interferon genes)dependent downstream signaling.Here we briefly describe the latest progress of the cGAS-cGAMP-STING pathway and its important role in antivirus,and provide new ideas for virus prevention research and new direction for the development of antiviral drugs.