复方骨肽注射液应用于胸腰椎骨质疏松性骨折患者中的效果及对患者骨密度与骨代谢的影响

Effect of compound bone peptide injection on osteoporotic fractures of thoracolumbar spine,bone density and bone metabolism

目的分析复方骨肽注射液在胸腰椎骨质疏松性骨折患者中的应用价值。方法选取2018年1月至2020年1月我院收治的96例胸腰椎骨质疏松性骨折患者为研究对象。所有患者随机分为甲组(钙尔奇D联合复方骨肽注射液治疗)和乙组(钙尔奇D治疗),各48例。比较两组治疗后的中医症状评分、骨代谢、骨质疏松程度、骨密度水平、视觉模拟评分(VAS)、腰椎疾患治疗成绩评分(JOA)。结果治疗后,甲组的中医症状评分、JOA评分均高于乙组(P<0.05);甲组的骨碱性磷酸酶(BALP)、Ⅰ型前胶原氨基端前肽(PIINP)水平明显低于乙组(P<0.05);3级骨质疏松患者比例甲组低于乙组(P<0.05),骨密度水平甲组高于乙组(P<0.05);VAS甲组低于乙组(P<0.05)。结论复方骨肽注射液治疗胸腰椎骨质疏松性骨折患者,可有效改善其骨代谢、骨密度水平,缓解疼痛程度,促进腰椎功能恢复。

Objective To evaluate the clinical value of compound bone peptide injection in patients with thoracolumbar osteoporotic fracture.Methods 96 patients admitted from January 2018 to January 2020 with thoracolumbar osteoporotic fracture were selected.The patients were randomly divided into group A(receiving calcine D with compound bone peptide injection)and group B(receiving calcine D treatment)with 48 patients in each group.TCM symptom scores,bone metabolism,degree of osteoporosis,bone density level,visual analogue scale(VAS)and lumbar spine disease treatment score(JOA)were compared between the two groups after treatment.Results After treatment,the TCM symptom score and JOA score in group A were higher than those in group B(P<0.05).The levels of bone alkaline phosphatase(BALP)and type I procollagen N-terminal propeptide(PIINP)in group A were significantly lower than those in group B(P<0.05).The grade 3 osteoporosis ratio in group A was lower than that in group B(P<0.05).The bone mineral density level in group A was higher than that in group B(P<0.05).The visual analogue scale(VAS)in group A was lower than that in group B(P<0.05).Conclusion The treatment of thoracolumbar osteoporotic fracture with compound bone peptide injection effectively improved the bone metabolism and bone mineral density,relieved pain and promoted the recovery of lumbar function.