铝碳酸镁联合四联疗法治疗幽门螺杆菌感染并十二指肠溃疡的临床效果

Clinical effect of Hydrotalcite combined with quadruple therapy in the treatment of helicobacter pylori infection and duodenal ulcer

目的探讨铝碳酸镁联合四联疗法治疗幽门螺杆菌(Hp)感染并十二指肠溃疡(DU)的临床效果。方法选取2017年5月至2019年12月于长江大学附属潜江市中心医院门诊就诊的108例DU伴有Hp感染的患者,依据随机数字表法将其分为对照组(n=54)和研究组(n=54)。对照组给予胶体酒石酸铋、泮托拉唑、克拉霉素、阿莫西林四联方案,研究组在此方案上联合应用铝碳酸镁。比较两组患者治疗后的临床疗效和Hp根除率,治疗前后的血清炎症因子水平变化。结果研究组患者的治疗总有效率和Hp根除率高于对照组,差异有统计学意义(P<0.05)。两组治疗前的炎症因子水平比较,差异无统计学意义(P>0.05);治疗后,研究组的血清白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)水平均低于对照组,差异有统计学意义(P<0.05)。结论铝碳酸镁联合四联疗法可改善DU伴有Hp感染患者的临床症状,提升Hp根除率,改善胃窦黏膜的炎症程度,降低炎症介质水平,增强疗效。

Objective To explore the clinical effect of Hydrotalcite combined with quadruple therapy in the treatment of helicobacter pylori(Hp)infection and duodenal ulcer(DU).Methods A total of 108 DU patients with HP infection who were visited in the outpatient department of Qianjiang Central Hospital Affiliated to Changjiang University from May 2017 to December 2019 were selected.According to the random digital table method,they were divided into control group(n=54)and study group(n=54).The control group was given a quadruple regimen of Colloidal Bismuth Tartrate,Pantoprazole,Clarithromycin and Amoxicillin.The study group was combined with Hydrotalcite on this regimen.The clinical efficacy and Hp eradication rate of the two groups of patients after treatment were compared,and the changes in serum inflammatory factor levels before and after treatment were compared.Results The total effective rate of treatment and Hp eradication rate in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the levels of inflammatory factors between the two groups before treatment(P>0.05).After treatment,the levels of serum interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α)in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion Hydrotalcite combined with quadruple therapy can improve the clinical symptoms of DU patients with Hp infection,increase the Hp eradication rate,reduce the level of inflammatory mediators,Improve the degree of inflammation of gastric antrum mucosa,and enhance the efficacy.