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降钙素原和D-二聚体与肺癌的相关性分析 被引量:1

Correlation analysis of procalcitonin and D-dimer with lung cancer
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摘要 目的分析降钙素原(PCT)和D-二聚体与肺癌的相关性。方法选取2020年6月至11月井冈山大学附属医院收治的63例肺癌患者作为观察组,并选取同期健康体检者36名为对照组。比较两组的PCT及D-二聚体水平,比较观察组中不同肺癌分期患者的PCT及D-二聚体水平,分析PCT及D-二聚体与肺癌发生及发展的相关性。结果观察组的PCT及D-二聚体水平均高于对照组,差异有统计学意义(P<0.05);ROC曲线分析显示,PCT及D-二聚体诊断肺癌的AUC分别为0.855、0.920,低于两者联合检测的AUC 0.967(P<0.05);观察组患者随癌症分期的进展,血清PCT及D-二聚体水平升高(P<0.05)。PCT及D-二聚体水平与肺癌分期进展呈正相关(P<0.05)。结论PCT及D-二聚体水平与肺癌的发生有关,可用于肺癌的早期筛查诊断,且PCT及D-二聚体水平还与肺癌的分期进展密切相关。 Objective To analyze the correlation between procalcitonin(PCT)and D-dimer and lung cancer.Methods A total of 63 patients with lung cancer admitted to Affiliated Hospital of Jinggangshan University were enrolled as observation group between June and November 2020,while other 36 healthy controls during the same period were enrolled as control group.The levels of PCT and D-dimer in the two groups were compared,and the levels of PCT and D-dimer in patients with different lung cancer stages in the observation group were compared,and the correlation between PCT and D-dimer and the occurrence and development of lung cancer was analyzed.Results PCT and D-dimer levels in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the AUC of PCT and D-dimer in the diagnosis of lung cancer was 0.855 and 0.920,respectively,lower than that of the combined detection of PCT and D-dimer(0.967)(P<0.05).The serum LEVELS of PCT and D-dimer in observation group increased with the progression of cancer stage(P<0.05).PCT and D-dimer levels were positively correlated with lung cancer stage progression(P<0.05).Conclusion The levels of PCT and D-dimer are related to the occurrence of lung cancer,which can be applied in the early screening and diagnosis of lung cancer.The levels of PCT and D-dimer are also closely related to the progression of lung cancer staging.
作者 周建中 ZHOU Jian-zhong(Department of Thoracic Surgery,Affiliated Hospital of Jinggangshan University,Jiangxi Province,Ji′an343000,China)
出处 《中国当代医药》 CAS 2021年第32期92-94,F0004,共4页 China Modern Medicine
基金 江西省吉安市指导性科技计划项目。
关键词 降钙素原 D-二聚体 肺癌 诊断 分期 相关性 Procalcitonin D-dimer Lung cancer Diagnosis Staging Correlation
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