无创正压通气在儿童重症支气管哮喘治疗中的效果

Effect of noninvasive positive pressure ventilation in the treatment of severe bronchial asthma in children

目的探讨无创正压通气(NIPPV)在儿童重症支气管哮喘治疗中的效果。方法选取新余市人民医院儿内科2017年1月至2020年9月收治的83例重症支气管哮喘患儿,按随机数字表法分为对照组(41例)与治疗组(42例)。对照组采用常规治疗,治疗组在此基础上给予无创正压通气治疗,两组患儿均观察24 h。比较两组患儿治疗后临床疗效及治疗前后不同时间的动脉血气变化。结果治疗组的临床总有效率高于对照组,差异有统计学意义(P<0.05);两组患儿治疗前氧分压(PO_(2))、二氧化碳分压(PCO_(2))、血氧饱和度(SaO_(2))水平比较,差异无统计学意义(P>0.05)。治疗后4、8、24 h,两组患儿的PO_(2)及SaO_(2)水平均高于治疗前,且治疗组的PO_(2)及SaO_(2)水平高于对照组,两组患儿的PCO_(2)水平均低于治疗前,且治疗组的PCO_(2)水平低于对照组,差异有统计学意义(P<0.05)。结论NIPPV可有效改善重症支气管哮喘患儿的临床症状,改善其呼吸功能,减少疾病对患儿机体的损伤,对患儿的恢复起积极的影响。

Objective To investigate the effect of noninvasive positive pressure ventilation(NIPPV)in the treatment of severe bronchial asthma in children.Methods A total of 83 children with severe bronchial asthma treated in the Department of Pediatrics of Xinyu People′s Hospital from January 2017 to September 2020 were selected as research objects and divided into the control group(41 cases)and the treatment group(42 cases)according to the random number table method.The control group received conventional treatment,and the treatment group was given noninvasive positive pressure ventilation on this basis.The children in both groups were observed for 24 h.The clinical efficacy and arterial blood gas changes at different time period before and after treatment were compared between the two groups.Results The total clinical effective rate of the treatment group was higher than that of the control group,the difference was statistically significant(P<0.05).There were no significant differences in the levels of partial pressure of oxygen(PO_(2)),partial pressure of carbon dioxide(PCO_(2))and blood oxygen saturation(SaO_(2))between the two groups before treatment(P>0.05).At 4,8 and 24 h after treatment,the levels of PO_(2) and SaO_(2) in the two groups were higher than those before treatment,and the levels of PO_(2) and SaO_(2) in the treatment group were higher than those in the control group,the levels of PCO_(2) in the two groups were lower than those before treatment,and the level of PCO_(2) in the treatment group was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion NIPPV can effectively improve the clinical symptoms of children with severe bronchial asthma,improve their respiratory function,reduce the diseases′damage to the children′s body,and have a positive impact on the children′s recovery.