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芪明颗粒联合七叶洋地黄双苷滴眼液治疗2型糖尿病干眼症的临床效果 被引量:6

Clinical effect of Qiming Granule combined with Esculin and Digitalis Glycosides Eye Drops in the treatment of type 2 diabetes mellitus dry eye
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摘要 目的探讨芪明颗粒联合七叶洋地黄双苷滴眼液治疗2型糖尿病(T2DM)干眼症的临床效果。方法选取2018年9月至2020年9月沈阳医学院附属中心医院眼科收治的120例干眼症合并T2DM患者作为研究对象,采用系统随机化方法分为试验组(60例)与对照组(60例)。对照组采用芪明颗粒口服方法,试验组采用芪明颗粒口服联合七叶洋地黄双苷滴眼液点眼治疗。比较两组治疗后的总有效率,比较两组治疗前后泪膜破裂时间(BUT)、泪液分泌试验(S1t)、荧光素染色(FL)检测结果。结果试验组的临床治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组的BUT、S1t、FL比较,差异无统计学意义(P>0.05);治疗后,两组的BUT、S1t、FL高于本组治疗前,差异有统计学意义(P<0.05);治疗后,试验组的BUT、S1t、FL高于同期对照组,差异有统计学意义(P<0.05)。结论芪明颗粒联合七叶洋地黄双苷滴眼液能够改善T2DM干眼症患者的干眼症状,并且安全有效。 Objective To investigate the clinical effect of Qiming Granule combined with Esculin and Digitalis Glycosides Eye Drops in the treatment of type 2 diabetes mellitus(T2DM)complicated with dry eye.Methods From September 2018 to September 2020,a total of 120 patients with dry eye complicated with T2DM admitted to the Department of Ophthalmology,Central Hospital Affiliated to Shenyang Medical College were selected as the research objects,and divided into the experimental group(60 cases)and the control group(60 cases)by systematic randomization.The control group was treated with Qiming Granule orally,while the experimental group was treated with Qiming Granule oral administration combined with Esculin and Digitalis Glycosides Eye Drops.The total effective rate after treatment was compared between the two groups,and the results of breaking up time(BUT),Sehirmer I test(S1t)and fuorescentstaining(FL)before and after treatment were compared between the two groups.Results The total effective rate of clinical treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).There were no statistically significant differences in BUT,S1t and FL between the two groups before treatment(P>0.05).After treatment,BUT,S1t and FL of the two groups were higher than those before treatment in the group,the differences were statistically significant(P<0.05).After treatment,BUT,S1t and FL of the test group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Qiming Granule combined with Esculin and Digitalis Glycosides Eye Drops can significantly improve dry eye symptoms in T2DM dry eye,and it is safe and effective.
作者 李春威 常丹 LI Chun-wei;CHANG Dan(Department of Ophthalmology,Central Hospital Affiliated to Shenyang Medical College,Liaoning Province,Shenyang110024,China)
出处 《中国当代医药》 CAS 2021年第32期140-143,共4页 China Modern Medicine
关键词 芪明颗粒 干眼症 七叶洋地黄双苷滴眼液 2型糖尿病 Qiming Granule Dry eye Esculin and Digitalis Glycosides Eye Drops Type 2 diabetes mellitus
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