急诊危重症伴快速心律失常患者实施胺碘酮治疗对其安全性及心功能的影响

The effect of amiodarone therapy on the safety and cardiac function of emergency critically ill patients with tachyarrhythmia

目的探究胺碘酮用于急诊危重症伴快速心律失常患者治疗中对其安全性及心功能的影响。方法184例急诊危重症伴快速心律失常患者,采用随机数字表法分为对照组及研究组,各92例。对照组予以去乙酰毛花苷注射液(商品名:西地兰)治疗,研究组予以胺碘酮治疗。对比两组患者的不良反应发生情况,治疗前后心功能指标(左心室舒张末期内径、左心室射血分数)。结果研究组患者的不良反应发生率4.35%低于对照组的19.57%,差异具有统计学意义(P<0.05)。治疗后,两组患者的左心室舒张末期内径小于本组治疗前、左心室射血分数高于本组治疗前,且研究组患者的左心室舒张末期内径(45.25±2.33)mm小于对照组的(52.69±2.47)mm、左心室射血分数(58.37±6.06)%高于对照组的(53.61±5.57)%,差异具有统计学意义(P<0.05)。结论急诊危重症伴快速心律失常患者予以胺碘酮治疗,心功能改善好,安全性高,值得推广应用。

Objective To investigate the effect of amiodarone therapy on the safety and cardiac function of emergency critically ill patients with tachyarrhythmia.Methods A total of 184 emergency critically ill patients with tachyarrhythmia were randomly divided into control group and research group by random numerical table,with 92 cases in each group.The control group was treated with deslanoside injection(trade name:Cedilanid),and the research group was treated with amiodarone.Both groups were compared in terms of occurrence of adverse reactions,and the cardiac function indicators(left ventricular end-diastolic diameter,left ventricular ejection fraction)before and after treatment.Results The incidence of adverse reactions 4.35%in the research group was lower than 19.57%in the control group,and the difference was statistically significant(P<0.05).After treatment,the left ventricular end-diastolic diameter of the two groups was less than those of this group before treatment,and the left ventricular ejection fraction was higher than that of this group before treatment;the left ventricular end-diastolic diameter(45.25±2.33)mm of the research group was less than(52.69±2.47)mm of the control group,and the left ventricular ejection fraction(58.37±6.06)%was higher than(53.61±5.57)%of the control group;all the differences were statistically significant(P<0.05).Conclusion Amiodarone treatment can improve the cardiac function of emergency critically ill patients with tachyarrhythmia with high safety,which is worthy of popularization and application.