多索茶碱联合布地奈德治疗慢阻肺急性加重期的疗效和安全性评价

Efficacy and safety of doxofylline combined with budesonide in the treatment of acute exacerbation of chronic obstructive pulmonary disease

目的探究多索茶碱联合布地奈德治疗慢性阻塞性肺疾病(慢阻肺)急性加重期的疗效和安全性,为临床实践提供理论依据。方法100例慢阻肺急性加重期患者,随机分为参照组与研究组,每组50例。两组患者入院后均统一接受常规吸氧、平喘、抗炎治疗,参照组患者实施布地奈德治疗,研究组患者在参照组基础上添加多索茶碱治疗。比较两组患者的治疗效果及不良反应发生情况。结果研究组患者治疗总有效率为98.0%,高于参照组的86.0%,差异有统计学意义(P<0.05)。研究组患者不良反应发生率为6.0%,与参照组的8.0%比较,差异无统计学意义(P>0.05)。结论慢阻肺急性加重期患者采用多索茶碱联合布地奈德治疗,能够有效缓解临床症状,提高治疗有效率,不良反应少,安全性高,治疗效果显著,可广泛应用于临床。

Objective To investigate the efficacy and safety of doxofylline combined with budesonide in the treatment of acute exacerbation of chronic obstructive pulmonary disease,so as to provide theoretical basis for clinical practice.Methods A total of 100 patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into the reference group and the research group,with 50 cases in each group.After admission,both groups received conventional oxygen inhalation,anti-asthmatic,and anti-inflammatory treatments.Patients in the reference group were treated with budesonide,and patients in the research group were treated with doxofylline on the basis of the reference group.The therapeutic effect and the occurrence of adverse reactions of the two groups were compared.Results The total effective rate of treatment in the research group was 98.0%,which was higher than 86.0%in the reference group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the research group was 6.0%,which was not statistically significant compared with 8.0%in the reference group(P>0.05).Conclusion Combination of doxofylline and budesonide has significant effect on patients with acute exacerbation of chronic obstructive pulmonary disease,and it can effectively relieve the clinical symptoms,increase the effective rate,with less adverse reactions and high and safety,which can be widely used in clinical practice.