慢性胆囊炎急性发作应用不同抗菌药物治疗的临床效果观察

Clinical effect of different antibiotics on acute attack of chronic cholecystitis

目的分析慢性胆囊炎急性发作应用不同抗菌药物治疗的临床效果。方法80例慢性胆囊炎急性发作患者,采用随机数字表法分为对照组和观察组,每组40例。对照组给予左氧氟沙星片治疗,观察组给予头孢唑林钠治疗。比较两组患者临床症状改善时间,相关临床指标[淀粉酶(AMY)、总胆红素(TBIL)以及白细胞计数(WBC)],炎性因子指标[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)],不良反应发生情况。结果观察组患者的饮食恢复时间为(5.70±0.38)d、恶心呕吐消失时间为(2.71±0.27)d、体温恢复时间为(2.42±0.23)d、腹痛消失时间为(3.51±0.33)d,均短于对照组的(9.00±0.43)、(5.01±0.38)、(5.72±0.43)、(5.81±0.44)d,差异具有统计学意义(P<0.05)。治疗后,观察组患者的AMY(37.82±2.22)IU/L、TBIL(16.41±2.32)μmol/L以及WBC(8.08±0.42)×10^(9)/L均低于对照组的(68.22±5.32)IU/L、(27.82±3.33)μmol/L、(11.30±0.57)×10^(9)/L,差异具有统计学意义(P<0.05)。治疗后,观察组患者的IL-6、IL-8、TNF-α以及CRP水平分别为(51.50±2.80)、(21.08±1.55)、(39.99±1.66)、(13.55±0.50)ng/ml,均低于对照组的(63.00±3.54)、(27.81±2.32)、(54.00±3.33)、(22.61±2.26)ng/ml,差异具有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论慢性胆囊炎急性发作患者应用头孢唑林钠治疗,可有效降低炎性因子水平,改善疾病相关指标以及临床症状,治疗效果以及治疗安全性均较高。

Objective To analyze the clinical effect of different antibiotics on acute attack of chronic cholecystitis.Methods A total of 80 patients with acute attack of chronic cholecystitis were divided into control group and observation group by random numerical table,with 40 cases in each group.The control group was treated with levofloxacin tablets,and the observation group was treated with cefazolin sodium.Both groups were compared in terms of improvement time of clinical symptoms,related clinical indicators[amylase(AMY),total bilirubin(TBIL)and white blood cell count(WBC)],inflammatory factor indicators[interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)],and occurrence of adverse reactions.Results The diet recovery time(5.70±0.38)d,the disappearance time of nausea and vomiting(2.71±0.27)d,the body temperature recovery time(2.42±0.23)d,and the abdominal pain disappearance time(3.51±0.33)d of the observation group were shorter than(9.00±0.43),(5.01±0.38),(5.72±0.43)and(5.81±0.44)d of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of AMY,TBIL and WBC of the observation group were(37.82±2.22)IU/L,(16.41±2.32)μmol/L and(8.08±0.42)/L,which were lower than(68.22±5.32)IU/L,(27.82±3.33)μmol/L and(11.30±0.57)/L of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of IL-6,IL-8,TNF-αand CRP in the observation group were(51.50±2.80),(21.08±1.55),(39.99±1.66)and(13.55±0.50)ng/ml,which were lower than (63.00±3.54), (27.81±2.32), (54.00±3.33) and (22.61±2.26) ng/ml in the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The application of cefazolin sodium in the treatment of acute attack of chronic cholecystitis can effectively reduce the level of inflammatory factors, improve disease-related indicators and clinical symptoms, with high therapeutic effect and safety.