泮托拉唑用于幽门螺杆菌阳性消化性溃疡伴上消化道出血患者治疗中的临床效果

Clinical effect of pantoprazole on the treatment of Helicobacter pylori-positive peptic ulcer patients with upper gastrointestinal hemorrhage

目的探析临床应用泮托拉唑治疗幽门螺杆菌阳性消化性溃疡伴上消化道出血的效果。方法100例幽门螺杆菌阳性消化性溃疡伴上消化道出血患者,基于信封法分为常规组与实验组,每组50例。常规组采用常规治疗方案,实验组在常规治疗方案的基础上使用泮托拉唑。比较两组患者的疗效,治疗前后的CD4+、CD8+水平,血清炎症因子[白细胞介素-1(IL-1)、C反应蛋白(CRP)]及胃泌素(GAS)水平、不良反应发生情况。结果实验组总有效率96.0%高于常规组的74.0%,差异具有统计学意义(P<0.05)。治疗后,实验组的CD4+(61.5±7.6)%、CD8+(42.0±7.1)%高于常规组的(57.9±8.9)%、(33.8±8.0)%,差异具有统计学意义(P<0.05)。治疗后,实验组的IL-1(18.05±4.01)ng/L、CRP(2.49±0.22)mg/dl、GAS(70.12±9.21)μmol/L低于常规组的(22.41±4.26)ng/L、(5.64±0.68)mg/dl、(84.88±8.11)μmol/L,差异具有统计学意义(P<0.05)。实验组不良反应发生率0低于常规组的8.0%,差异具有统计学意义(P<0.05)。结论泮托拉唑治疗幽门螺杆菌阳性消化性溃疡伴上消化道出血患者的效果显著,推动消化性溃疡伴出血症状加速恢复,不良反应可控,应用价值高。

Objective To discuss and analyze the effect of pantoprazole on the treatment of Helicobacter pylori-positive peptic ulcer patients with upper gastrointestinal hemorrhage.Methods A total of 100 cases of Helicobacter pylori-positive peptic ulcer patients with upper gastrointestinal hemorrhage were divided into conventional group and experimental group based on the envelope method,with 50 cases in each group.The conventional group was treated with conventional therapy,and the experimental group was treated with pantoprazole on the basis of the conventional therapy.Both groups were compared in terms of clinical efficacy,CD4+and CD8+levels,serum inflammatory factors[interleukin-1(IL-1),C-reactive protein(CRP)]and gastrin(GAS)levels before and after treatment,and occurrence of adverse reactions.Results The total effective rate 96.0%of the experimental group was higher than 74.0%of the conventional group,and the difference was statistically significant(P<0.05).After treatment,CD4+(61.5±7.6)%and CD8+(42.0±7.1)%of the experimental group were higher than(57.9±8.9)%and(33.8±8.0)%of the conventional group,and the difference was statistically significant(P<0.05).After treatment,IL-1(18.05±4.01)ng/L,CRP(2.49±0.22)mg/dl,GAS(70.12±9.21)μmol/L of the experimental group were lower than(22.41±4.26)ng/L,(5.64±0.68)mg/dl,(84.88±8.11)μmol/L of the conventional group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 0 in the experimental group was lower than 8.0%in the conventional group,and the difference was statistically significant(P<0.05).Conclusion Pantoprazole has significant effect on Helicobacter pylori-positive peptic ulcer patients with upper gastrointestinal hemorrhage,and it can accelerate the recovery of peptic ulcer with bleeding symptoms with manageable adverse effects,which contains high therapeutic value.