血清Ⅳ型胶原水平在结直肠癌肝转移中的应用价值

The Clinical Application Value of Type Ⅳ Collagen in Liver Metastasis of Colorectal Cancer

目的通过检测结直肠癌患者血清Ⅳ型胶原的水平,探讨其在结直肠癌肝转移中的应用价值。方法收集在中国医学科学院肿瘤医院就诊的220例结直肠癌患者(其中发生肝转移的145例,未发生肝转移的75例)以及80例健康体检人群的血清样本,检测血清中Ⅳ型胶原的水平,检测方法为乳胶免疫比浊法。结果结直肠癌组血清Ⅳ型胶原水平明显高于健康对照组(P<0.05),结直肠癌肝转移组血清Ⅳ型胶原水平明显高于结直肠癌组(P<0.05)和健康对照组(P<0.05)。结直肠癌肝转移组治疗前血清Ⅳ型胶原水平明显高于结直肠癌组(P<0.05)。结直肠癌肝转移组治疗后患者与治疗前患者相比,血清Ⅳ型胶原水平明显降低(P<0.05)。进行肝转移瘤切除术的结直肠癌肝转移患者,术后30天内的血清Ⅳ型胶原水平明显高于术后30天以上水平(P<0.05)。结论血清Ⅳ型胶原水平在结直肠癌肝转移患者的辅助诊断及治疗监测方面具有一定的应用价值,可以作为结直肠癌患者治疗监测的检测指标之一。

Objective To investigate the clinical application value of type Ⅳ collagen in colorectal cancer patients with liver metastasis through detecting the level of serum type Ⅳ collagen.Methods Serum samples were collected from 220 colorectal cancer patients(145 patients with liver metastasis and 75 patients without liver metastasis) and 80 healthy people in Cancer Hospital of Chinese Academy of Medical Sciences. The level of type Ⅳ collagen was detected by latex immunoturbidimetry for all subjects.Results The level of type Ⅳ collagen in the colorectal cancer group was significantly higher than that in the healthy control group(P<0.05). The level of type Ⅳ collagen in the colorectal cancer liver metastasis group was significantly higher than that in the colorectal cancer group(P<0.05) and healthy control group(P<0.05). The level of type Ⅳ collagen in the colorectal cancer liver metastasis group was significantly higher than that in the colorectal cancer group before treatment(P<0.05). Compared with the patients before treatment, the level of type Ⅳ collagen in the colorectal cancer liver metastasis group was significantly lower after treatment(P<0.05). The level of type Ⅳ collagen in colorectal cancer patients with liver metastasis who underwent liver metastasis resection within 30 days after operation was significantly higher than that of more than 30 days after operation(P<0.05).Conclusion Type Ⅳ collagen has a certain application value in the auxiliary diagnosis and treatment monitoring of colorectal cancer patients with liver metastasis, and can be used as one of the indicators for treatment monitoring of colorectal cancer patients.