胃癌患者血清肿瘤标志物表达水平与临床病理特征的相关性

Correlation between serum tumor markers and clinicopathological characteristics in patients with gastric cancer

目的观察胃癌患者血清肿瘤标志物的表达水平,并分析其与临床病理特征的相关性。方法选取60例胃癌患者为试验组,60名健康者为对照组。比较两组的CA19-9、CA72-4、CA125和CEA水平;分析胃癌患者血清肿瘤标志物表达水平与临床病理特征的关系。结果试验组的CA19-9、CA72-4、CA125和CEA水平均显著高于对照组,差异具有统计学意义(P<0.05)。不同分化程度胃癌患者的血清CA125和CEA表达水平比较,差异具有统计学意义(P<0.05);不同浸润深度胃癌患者的血清CA19-9和CA72-4表达水平比较,差异具有统计学意义(P<0.05);淋巴结有、无转移胃癌患者的血清CA72-4、CA125和CEA表达水平比较,差异具有统计学意义(P<0.05);不同Her2表达情况胃癌患者的血清CA19-9、CA72-4和CEA表达水平比较,差异有统计学意义(P<0.05)。结论胃癌患者血清肿瘤标志物CA19-9、CA72-4、CA125和CEA均呈现高表达,对胃癌诊断具有重要提示作用;血清肿瘤标志物的阳性表达与临床病理特征之间存在密切联系,对胃癌病情进展评估及治疗方案的制定具有参考意义。

Objective To observe the expression level of serum tumor markers in patients with gastric cancer,and to analyze the correlation between the expression level and clinicopathological characteristics.Methods Sixty patients with gastric cancer were selected as experimental group and 60 healthy subjects as control group.The levels of CA19-9,CA72-4,CA125 and CEA were compared between the two groups.The correlation between the expression level of serum tumor markers and clinicopathological characteristics in patients with gastric cancer was analyzed.Results The levels of CA19-9,CA72-4,CA125 and CEA in the experimental group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).There were significant differences in the expression levels of serum CA125 and CEA in patients with different degrees of gastric cancer(P<0.05);there were significant differences in the expression levels of serum CA19-9 and CA72-4 in patients with different invasion depth of gastric cancer(P<0.05);there were significant differences in the expression levels of serum CA72-4,CA125 and CEA in patients with lymph node metastasis of gastric cancer and without lymph node metastasis of gastric cancer(P<0.05);there were significant differences in the expression levels of serum CA19-9,CA72-4 and CEA in patients with different Her2 expression of gastric cancer(P<0.05).Conclusion The serum tumor markers CA19-9,CA72-4,CA125 and CEA were all highly expressed in patients with gastric cancer,which has important implications for the diagnosis of gastric cancer;the positive expression of serum tumor markers is closely related to clinicopathological characteristics,which has reference significance for the evaluation of the progression and formulation of treatmeat plan of gastric cancer.