摘要
以2,4-二甲基吡咯和3,5-二溴苯甲醛为原料,合成中间体1,然后与对溴苯甲醛通过克脑文盖尔(Knoevenagel)反应延长侧链,增强共轭效应,得到目标产物即氟硼二吡咯-2(boron dipyrromethene-2,BODIPY-2),其结构经^(1)H NMR(核磁共振,nuclear magnetic resonance)、^(13)C NMR和质谱等验证。探究反应温度、时间和投料比,确认最优条件。紫外-荧光光谱测试表明,该化合物出现在近红外区域,是一种非常有应用前景的BODIPY类荧光探针。
In this paper, 2, 4-dimethylpyrrole and 3, 5-dibromobenzaldehyde are used as raw materials to synthesize intermediate 1, which is then reacted with p-bromobenzaldehyde through Knoevenagel reaction to extend the side chain, enhance the conjugation effect, and obtain the target product, namely boron dipyrromethene-2(BODIPY-2). Its structure has been verified by ^(1)H NMR(nuclear magnetic resonance),^(13)C NMR and mass spectrum. The reaction temperature, time and feed ratio to confirm the optimal conditions have been explored. The UV-fluorescence spectrum test shows that the compound appears in the near-infrared region and is a very promising BODIPY fluorescent probe.
作者
田琪
卢俊瑞
谢志强
卢博为
刘金彪
TIAN Qi;LU Junrui;XIE Zhiqiang;LU Bowei;LIU Jinbiao(School of Chemistry and Chemical Engineering,Tianjin University of Technology,Tianjin 300384,China;College of Chemistry,Nankai University,Tianjin 300071,China;School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;Tianjin Ruiling Chemical Engineering Co.,Ltd.,Tianjin 300384,China)
出处
《天津理工大学学报》
2021年第4期1-3,15,共4页
Journal of Tianjin University of Technology
基金
国家自然科学基金(21476174,21176194)。
