黄连温胆汤治疗室性期前收缩有效性和安全性的系统评价

Effectiveness and Safety of Huanglian Wendan Decoction in the Treatment of Premature Ventricular Contraction:a Meta-analysis

目的系统评价黄连温胆汤联合常规西药治疗室性期前收缩的有效性及安全性。方法检索中国知网、维普、万方、PubMed、the Cochrane Library、EMbase等数据库,搜集1990年1月—2021年1月关于黄连温胆汤治疗室性期前收缩的随机对照研究(RCT),然后由2名研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险,应用RevMan 5.3软件进行Meta分析。结果最终纳入13篇RCT,涉及946例病人。Meta分析结果显示:与常规西药治疗比较,在常规西药治疗基础上联合黄连温胆汤治疗室性期前收缩总有效率升高[OR=3.63,95%CI(2.52,5.23),P<0.00001],24 h室性期前收缩次数减少[MD=-408.55,95%CI(-733.21,-83.89),P=0.01],中医证候积分改善[MD=-5.53,95%CI(-10.90,-0.15),P=0.04]。结论现有证据表明,联合黄连温胆汤治疗室性期前收缩能减少室性期前收缩次数,改善中医证候,提高临床疗效。

Objective To evaluate the clinical efficacy and safety of Huanglian Wendan Decoction combined with conventional western medicine in the treatment of premature ventricular contraction.Methods CNKI,VIP,Wanfang,PubMed,the Cochrane Library,EMbase,and other databases were searched for the randomized controlled trial(RCT)of Huanglian Wendan Decoction in the treatment of premature ventricular contraction from January 1990 to January 2021.Then,two researchers independently screened the literature,extracted the data,and evaluated the risk of bias in the included studies.Meta-analysis was performed using RevMan 5.3 software.Results Thirteen RCTs involving 946 patients were included.Meta-analysis results showed that,Huanglian Wendan Decoction with western medicine could increase the total effective rate[OR=3.63,95%CI(2.52,5.23),P<0.00001],decrease the total number of 24-hour premature ventricular beats[MD=-408.55,95%CI(-733.21,-83.89),P=0.01],improve TCM syndromes[MD=-5.53,95%CI(-10.90,-0.15),P=0.04].Conclusion Huanglian Wendan Decoction with western medicine can more effectively reduce the frequency of ventricular premature beats,alleviate the TCM syndromes,and improve the effectiveness of the treatment of ventricular premature beats.