比索洛尔联合辛伐他汀治疗老年不稳定型心绞痛的Meta分析

Bisoprolol Combined with Simvastatin in the Treatment of Senile Unstable Angina:a Meta-analysis

目的基于Meta分析系统评价比索洛尔联合辛伐他汀治疗老年不稳定型心绞痛的疗效及安全性。方法计算机检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、PubMed、the Corchrane Library及EMbase,收集有关比索洛尔联合辛伐他汀治疗老年不稳定型心绞痛的临床随机对照试验(RCT),文献检索年限为建库至2020年3月,采用RevMan 5.3软件进行Meta分析。结果共纳入26项RCT,涉及2527例病人。Meta分析结果显示:与单用辛伐他汀相比,比索洛尔联合辛伐他汀治疗老年不稳定型心绞痛可明显提高心绞痛症状疗效[RR=1.25,95%CI(1.20,1.29),P<0.00001],提高心电图改善率[RR=1.38,95%CI(1.18,1.61),P<0.0001],减少心绞痛发作频次[MD=-2.26,95%CI(-2.56,-1.97),P<0.00001],缩短心绞痛发作持续时间[MD=-2.14,95%CI(-2.24,-2.05),P<0.00001]。结论现有证据表明,比索洛尔联合辛伐他汀治疗老年不稳定型心绞痛可明显提高临床疗效及心电图改善率,减少心绞痛发作频次及发作持续时间,且有较好的安全性。

Objective To evaluate the efficacy and safety of bisoprolol combined with simvastatin in the treatment of senile unstable angina pectoris based on a Meta-analysis system.Methods CNKI,Wanfang,VIP,PubMed,the Corchrane Library,and EMbase were searched by computer to collect the randomized controlled trials(RCTs)of Bisoprolol combined with Simvastatin for the treatment of senile unstable angina pectoris from the establishment of the database to March 2020.Meta analysis was conducted with RevMan 5.3 software.Results A total of 26 RCTs were included,involving 2527 patients.The Meta-analysis results showed that compared with control group,bisoprolol combined with simvastatin in the treatment of unstable angina pectoris in the elderly could improve the clinical efficacy[RR=1.25,95%CI(1.20,1.29),P<0.00001],increase electrocardiogram improvement rate[RR=1.38,95%CI(1.18,1.61),P<0.00001],reduce the frequency of angina attacks[MD=-2.26,95%CI(-2.56,-1.97),P<0.00001],and reduce the duration of angina attacks[MD=-2.14,95%CI(-2.24,-2.05),P<0.00001].Conclusion The available evidence suggests that bisoprolol combined with simvastatin in the treatment of senile unstable angina pectoris can significantly improve the clinical efficacy,reduce the frequency and duration of angina attack,with better safety.