盐酸氨溴索对慢阻肺合并肺部感染患者动脉血气指标及肺功能水平的影响

Effect of Ambroxol Hydrochloride on Arterial Blood Gas Index and Pulmonary Function in COPD Patients with Pulmonary Infection

目的:探讨盐酸氨溴索对慢阻肺合并肺部感染患者动脉血气指标及肺功能水平的影响。方法:选取2018年1月-2021年1月本院收治的98例慢阻肺合并肺部感染患者,随机分为两组,对照组进行常规治疗,研究组进行盐酸氨溴索治疗。比较两组治疗效果、X线片吸收率、细菌清除率、心率、呼吸频率、血气指标、生活质量及肺功能。结果:对照组、研究组治疗有效率分别为83.7%、95.9%,X线片吸收率分别为77.6%、85.7%,细菌清除率分别为75.5%、87.8%,与对照组比较,研究组治疗有效率、X线片吸收率、细菌清除率更高(P<0.05);与对照组比较,治疗后研究组心率、呼吸频率更低(P<0.05);治疗前,两组PaO_(2)、SpO_(2)、PaCO_(2)水平差异无统计学意义(P>0.05),治疗后与对照组相比,研究组的PaO_(2)、SpO_(2)水平更高,PaCO_(2)水平更低(P<0.05);治疗前,两组社会、躯体、角色、认知功能评分差异无统计学意义(P>0.05),治疗后,两组生活质量评分均明显提升,但较对照组,研究组生活质量评分提升更明显,差异有统计学意义(P<0.05);治疗前,两组肺功能差异无统计学意义(P>0.05),治疗后,两组肺功能水平均明显升高,且与对照组比较,研究组肺功能水平升高更明显,差异有统计学意义(P<0.05)。结论:对慢阻肺合并肺部感染患者进行盐酸氨溴索治疗,效果理想,可改善肺功能及血气指标,调节心率及呼吸频率,有利于病情恢复及生活质量的提升,具有非常高的临床应用价值,值得广泛应用。

Objective:To investigate the effect of Ambroxol Hydrochloride on arterial blood gas index and pulmonary function in chronic obstructive pulmonary disease patients with pulmonary infection.Method:A total of 98 patients with pulmonary infection and chronic obstructive pulmonary disease in our hospital from January 2018 to January 2021 were randomly divided into two groups,the control group was treated with regular treatment,the study group was treated with Ambroxol Hydrochloride treatment.The therapeutic effect,X ray film absorption rate,bacterial clearance rate,heart rate,respiratory rate,blood gas index,quality of life and lung function were compared between the two groups.Result:The effective rates of treatment in the control group and the study group were 83.7%,95.9%,the X ray film absorption rate in the control group and the study group were 77.6% and 85.7%,and the bacterial clearance rates in the control group and the study group were 75.5% and 87.8%,respectively.Compared with the control group,the effective rate,X ray film absorption rate and bacterial clearance rate of the study group were higher(P<0.05);compared with the control group,the heart rate and respiratory rate of the study group were lower(P<0.05);before treatment,there were no significant differences in PaO_(2),SpO_(2) and PaCO_(2) levels between the two groups(P>0.05),compared with the control group,PaO_(2) and SpO_(2) levels were higher and PaO_(2) levels were lower in the study after treatment(P<0.05);before treatment,there were no significant differences in social,physical,role and cognitive function between the two groups(P>0.05),after treatment,the quality of life scores of the two groups were significantly improved,but the quality of life scores of the study group were significantly higher than that of the control group(P<0.05);before treatment,there were no significant differences in lung function between the two groups(P>0.05),after treatment,the levels of lung function were significantly increased,and compared with the control group,the pulmonary function levels of the study group were higher(P<0.05).Conclusion:Ambroxol Hydrochloride is effective for patients with pulmonary infection and chronic obstructive pulmonary infection.It can improve lung function and blood gas indexes,regulate heart rate and respiratory rate,and benefit the recovery of the disease,and improve the quality of life of patients,which has a very high clinical application value.It is worth widely application.