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优甲乐联合夏枯草对桥本甲状腺炎伴甲减患者的疗效及机制分析 被引量:14

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摘要 目的探讨优甲乐联合夏枯草对桥本甲状腺炎伴甲减患者的疗效及机制。方法选择桥本甲状腺炎伴甲减患者200例,随机分为对照组和观察组,各100例。对照组空腹口服优甲乐,观察组在优甲乐的基础上联用夏枯草口服液。结果观察组的有效率明显高于对照组(P<0.05)。治疗后,两组的TSH、FT_(3)、TPO-Ab、TG-Ab和FT_(4)水平明显改善(P<0.05),且观察组优于对照组(P<0.05);两组的甲状腺三径值明显减小(P<0.05),观察组更小(P<0.05);两组的TG和TC水平明显降低(P<0.05),观察组更低(P<0.05);两组的血清IL-12和IFN-γ水平明显降低(P<0.05),IL-4及IL-10水平明显升高(P<0.05),且观察组优于对照组(P<0.05)。结论优甲乐联合夏枯草口服液能有效提高优甲乐治疗效果,纠正机体的免疫紊乱,改善甲状腺肿大,改善桥本甲状腺炎伴甲减患者的脂类代谢功能。
出处 《贵州医药》 CAS 2021年第11期1704-1705,共2页 Guizhou Medical Journal
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