特布他林联合孟鲁司特治疗儿童支气管哮喘急性发作合并支气管肺炎的效果及对肺功能、免疫功能的影响

Effect of Terbutaline Combined with Montelukast in the Treatment of Children with Acute Attack of Bronchial Asthma Complicated with Bronchopneumonia and Its Effect on Lung Function and Immune Function

目的:探讨特布他林联合孟鲁司特治疗儿童支气管哮喘急性发作合并支气管肺炎的效果及对肺功能、免疫功能的影响。方法:选取2016年1月-2021年1月笔者所在医院收治的150例支气管哮喘急性发作合并支气管肺炎患儿。按照随机数字表法将其分为对照组与观察组,每组75例。对照组给予常规治疗,观察组在对照组基础上给予特布他林联合孟鲁司特治疗。比较两组临床疗效、肺功能指标[每分钟静息通气量(minute ventilation volume,MV)和潮气量(tidal volume,VT)]、免疫功能指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))及不良反应。结果:观察组总有效率为96.00%,明显高于对照组的82.67%,差异有统计学意义(P<0.05)。治疗后,两组肺功能指标及免疫功能指标均较治疗前明显改善(P<0.05)。观察组治疗后MV(4.52±1.03)L,VT(8.47±0.59)ml/kg,CD4^(+)(38.61±6.24)%,CD4^(+)/CD8^(+)(1.83±0.25),均高于对照组的(3.89±0.64)L、(7.04±0.33)ml/kg、(33.54±5.19)%、(1.24±0.16),差异有统计学意义(P<0.05)。观察组治疗后CD8^(+)(22.61±1.25)%,低于对照组的(27.45±3.93)%,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:特布他林联合孟鲁司特对支气管哮喘急性发作合并支气管肺炎患儿具有很好的治疗效果及很高的安全性,能有效改善患儿的肺功能及免疫功能。

Objective:To investigate the effect of Terbutaline combined with Montelukast in the treatment of children with acute attack of bronchial asthma complicated with bronchopneumonia and its effect on lung function and immune function.Method:A total of 150 children with acute attack of bronchial asthma complicated with bronchopneumonia admitted in our hospital from January 2016 to January 2021 were selected.According to the random number table method,they were divided into the control group and the observation group,with 75 cases in each group.The control group was given routine treatment,and the observation group was given Terbutaline combined with Montelukast on the basis of control group.The clinical efficacy,lung function indexes[minute ventilation volume(MV)and tidal volume(VT)],immune function indexes(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))and adverse reactions were compared between two groups.Result:The total effective rate in the observation group was 96.00%,which was significantly higher than 82.67%in the control group,the difference was statistically significant(P<0.05).After treatment,the lung function indexes and immune function indexes in both groups were significantly improved compared with those before treatment(P<0.05).After treatment,MV(4.52±1.03)L,VT(8.47±0.59)ml/kg,CD4^(+)(38.61±6.24)%,CD4^(+)/CD8^(+)(1.83±0.25)in the observation group were higher than(3.89±0.64)L,(7.04±0.33)ml/kg,(33.54+5.19)%,(1.24±0.16)in the control group,the differences were statistically significant(P<0.05).After treatment,CD8^(+)in the observation group was(22.61±1.25)%,which was lower than(27.45±3.93)%in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Terbutaline combined with Montelukast has a good therapeutic effect and high safety for children with acute attack of bronchial asthma complicated with bronchopneumonia.It can effectively improve the lung function and immune function of children.