温胆汤加减治疗脑梗死恢复期伴抑郁的效果观察

Effect of Wendan Decoction Modified in the Treatment of Cerebral Infarction in Convalescence with Depression

目的:观察温胆汤加减治疗脑梗死恢复期伴抑郁的临床效果。方法:选取2017年10月-2020年10月笔者所在医院收治的脑梗死恢复期伴抑郁患者64例作为研究对象,采用随机数字表法将其分为对照组和观察组,各32例。对照组给予常规治疗,观察组在对照组基础上给予温胆汤加减治疗。比较两组临床疗效、治疗前后美国国立卫生研究院卒中量表(NIHSS)、汉密尔顿抑郁量表-17项(HAMD-17)评分及不良反应发生情况。结果:观察组治疗总有效率为93.75%,高于对照组的75.00%,差异有统计学意义(P<0.05)。两组治疗后NIHSS、HAMD-17项评分均较治疗前降低,差异有统计学意义(P<0.05);观察组治疗后NIHSS、HAMD-17项评分均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:温胆汤加减治疗脑梗死恢复期伴抑郁的临床效果显著,可同时改善神经功能缺损症状及抑郁症状,且未增加不良反应发生率,值得临床推广应用。

Objective:To observe the clinical effect of Wendan Decoction modified in the treatment of cerebral infarction in convalescence with depression.Method:A total of 64 patients with cerebral infarction in convalescence with depression admitted in our hospital from October 2017 to October 2020 were selected as the research objects.They were divided into the control group and the observation group by random number table method,with 32 cases in each group.The control group was given routine treatment,and the observation group was given Wendan Decoction modified on the basis of the control group.The clinical efficacy,national institutes of health stroke scale(NIHSS),Hamilton depression scale 17 items(HAMD-17)scores before and after treatment and the incidence of adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was 93.75%,which was higher than 75.00%of the control group,the difference was statistically significant(P<0.05).After treatment,NIHSS and HAMD-17 scores of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).The NIHSS and HAMD-17 scores of the observation group were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Wendan Decoction modified has a significant clinical effect in the treatment of cerebral infarction in convalescence with depression.It can improve the symptoms of neurological deficit and depression at the same time,and does not increase the incidence of adverse reactions.It is worthy of clinical application.