抗核抗体谱对急性主动脉综合征的影响

Effect of antinuclear antibodies on acute aortic syndrome

目的探讨抗核抗体谱(ANAs)对急性主动脉综合征(AAS)的影响。方法纳入2019年12月至2020年12月保定市第一中心医院收治的AAS胸痛患者77例为AAS组,同期选取非AAS胸痛患者76例为对照组。比较两组患者临床特征、实验室指标;AAS发生的影响因素采用Logistic回归分析。结果AAS组男性、高血压发生率、动脉粥样硬化发生率、吸烟率、收缩压、舒张压和平均动脉压均高于对照组患者;白细胞计数、C反应蛋白、D-二聚体、高敏肌钙蛋白Ⅰ、血肌酐、血糖水平高于对照组患者;ANAs阳性率高于对照组患者,差异有统计学意义(P<0.05);合并高血压、合并动脉粥样硬化、白细胞计数升高及ANAs阳性是AAS的独立危险因素(P<0.05)。结论ANAs阳性患者在AAS患者中占比较高,并且ANAs阳性是AAS的独立危险因素。

Objective To investigate the effect of antinuclear antibodies(ANAs)on acute aortic syndrom(AAS).Method A total of 77 AAS patients with chest pain treated in Baoding No.1 Central Hospital from December 2019 to December 2020 were included as AAS group,and 76 non AAS patients with chest pain were selected as the control group in the same period.The clinical characteristics and laboratory indexes of the two groups were compared,and the influencing factors of AAS were analyzed by Logistic regression.Result The incidence of hypertension,atherosclerosis,smoking,systolic blood pressure,diastolic blood pressure and mean arterial pressure in males of AAS group were higher than those in control group;levels of leukocyte count,C-reactive protein,D-dimer,high-sensitivity troponin I,serum creatinine and blood glucose were higher than those in the control group;positive rate of ANAs was significantly higher than that in the control group(P<0.05);concomitant hypertension,atherosclerosis,elevated leukocytes and positive ANAs were independent risk factors for AAS(P<0.05).Conclusion ANAs positive patients accounted for a high proportion in patients with AAS,and positive ANAs is an independent risk factor for AAS.