黄烷-3-醇类化合物在体内的吸收、代谢特征与机制研究进展

Recent Progress in Understanding the Characteristics and Mechanisms of Flavan-3-ols Absorption and Metabolism in Humans

黄烷-3-醇类化合物是人类饮食中含量最丰富的膳食多酚之一,近年来,黄烷-3-醇类化合物备受关注,这主要是因为许多研究发现其与很多慢性疾病风险的降低和代谢综合征的缓解密切相关,但黄烷-3-醇类化合物在体内发挥的作用一定程度上取决于其被摄入后的吸收和代谢,尤其是肠道微生物的分解代谢。因此,本文将重点探讨黄烷-3-醇类化合物的吸收、代谢及其生物转化的途径,有助于揭示其在体内的生物学作用。

Flavan-3-ols are one of the most abundant classes of dietary polyphenols in the human diet.In recent years,flavan-3-ols have attracted much attention because many studies have found that they are associated with reduced risks of many chronic diseases and alleviation of metabolic syndromes.However,the role of flavan-3-ols in the body depends to a certain extent on their absorption and metabolism after being ingested,especially their catabolism by intestinal microbes.In this context,this article focuses on reviewing the signaling pathways related to the absorption,metabolism and biotransformation of flavan-3-ols,which will be helpful for understanding their biological effects in the body.