哺乳动物卵泡相关代谢组学研究进展

Research Progress in Metabolomics of Mammalian Follicles

卵母细胞质量是决定辅助生殖结局的一项重要因素,创建一种简单可靠的卵母细胞质量评价体系有助于提高辅助生殖的成功率。新兴的代谢组学有望成为评估卵母细胞质量的新方法。目前,代谢组学已广泛应用于女性生殖相关的科学研究,通过对卵母细胞、颗粒细胞和卵泡液等样品中的中小分子进行定性和定量分析,研究者们寻找到多种与女性不孕相关的标志性代谢物,涉及糖类、脂质和氨基酸等多种物质的代谢,对于临床不孕症的诊断和治疗具有潜在的应用价值。综述近年哺乳动物卵泡相关的代谢组学研究。

The oocyte quality is one of the determining factors of successful assisted reproductive technology(ART)outcome.It is beneficial to establish a simple and reliable evaluation system of oocyte quality for improving the success rate of ART.Newly developed metabolomics is expected to provide a new method for evaluating oocyte quality.At present,metabolomics has been used in many relevant studies of female reproduction.By the qualitative and quantitative analysis of small and medium-sized molecules in oocytes,granulosa cells and follicular fluid samples,researchers have identified a variety of symbolic metabolites related to female infertility,which are involved in the metabolism of carbohydrate,lipid,amino acid and other substances.These studies have showed the potential application of metabolomics in the diagnosis and treatment of infertility.We review the research progress in the metabolomics of mammalian follicles.