微小RNA在子宫内膜蜕膜化中的功能

Research Progress on the Function of MicroRNA in Decidualization

子宫内膜蜕膜化是子宫内膜在排卵期后转化为分泌期至胚胎着床期间发生的持续的形态和功能变化,对妊娠的建立、维持及内膜的周期性变化至关重要。子宫内膜基质细胞的蜕膜化是其中最重要的改变。这一过程由孕酮和环磷酸腺苷信号驱动,伴随着一系列标志性分子的表达改变。微小RNA(miRNA)在基因表达的转录后调控中起着广泛并且非常重要的作用。大量研究显示,miRNA通过调控胰岛素样生长因子结合蛋白1(IGFBP1)、催乳素(PRL)、Krüppel样因子12(KLF12)和同源框基因A10(HOXA10)等基因表达,在子宫内膜蜕膜化及相关疾病发病中发挥重要的作用。现就miRNA合成酶和一些miRNA在蜕膜化中发挥的作用及其分子机制进行综述,以期为蜕膜化及其相关疾病,如反复种植失败、子宫内膜异位症和子痫前期等的诊疗提供更多的理论依据。

Decidualization is the process of morphological and functional changes of the endometrium from the secretory period to embryo implantation after ovulation.It is very important for the establishment and maintenance of pregnancy and the cyclical changes of endometrium.The transformation of endometrial stromal cell is most important,which is driven by progesterone and cAMP signals and is accompanied by changes in the expressions of a series of marker molecules.MicroRNAs(miRNAs)play an extensive role in the post transcriptional regulation.A large number of studies have shown that miRNAs are involved in the regulation of decidualization related genes,such as IGFBP1,PRL,KLF12 and HOXA10.This article summarizes the role of miRNA synthesis related enzymes and miRNAs in the process of decidualization,which provides more information for the study of decidualization and related diseases such as repeated implantation failure,endometriosis,preeclampsia and other female diseases.