环状RNA在多囊卵巢综合征发生发展中的作用

Circular RNA in Pathophysiology of Polycystic Ovary Syndrome

多囊卵巢综合征(PCOS)是育龄期女性最常见的生殖内分泌疾病,发病率逐年增高。PCOS的临床表现具有高度异质性,且导致患者生活质量不同程度地下降。越来越多的证据表明,PCOS可能是一种复杂的多基因疾病,受到表观遗传和环境等多种因素的影响。一些研究对PCOS患者的卵巢组织、胎盘组织进行高通量测序或基因芯片分析,发现多种环状RNA(circRNA)存在差异表达,如hsa_circ_0006877、hsa_circ_0118530。这些差异表达的circRNA可能通过参与卵巢颗粒细胞增殖和凋亡、雄激素的合成和释放等影响卵母细胞的发育以及生殖内分泌平衡。综述circRNA在PCOS发生发展中的作用,为PCOS的临床治疗提供新思路。

Polycystic ovary syndrome(PCOS)is one of the most common reproductive endocrine diseases in women of childbearing age,and the incidence of PCOS increased year by year.The clinical manifestations of PCOS are highly heterogeneous,leading to different degrees of decline in the life quality of patients.There is growing evidence that PCOS may be a complex polygenetic disease with strong epigenetic and environmental influences.Some studies conducted high-throughput sequencing or gene chip analysis on ovarian tissues and placental tissues of PCOS patients found multiple differentially expressed circRNA,such as hsa_circ_0006877,hsa_circ_0118530.These differentially expressed circRNA may affect oocyte development and reproductive endocrine balance through their involvement in the ovarian granulosa cell proliferation and apoptosis,androgen synthesis and release.This article reviews the role of circRNA in the occurrence and development of PCOS.