硫酸沙丁胺醇与布地奈德混悬液联合异丙托溴铵雾化吸入治疗慢性阻塞性肺疾病急性加重期的临床观察

Salbutamol Sulfate and Budesonide Suspension Combined with Ipratropium Bromide Aerosol Inhalation in the Treatment of Patients with Acute Exacerbation Chronic Obstructive Pulmonary Disease

目的:分析硫酸沙丁胺醇与布地奈德混悬液联合异丙托溴铵雾化吸入治疗慢性阻塞性肺疾病急性加重期的临床效果。方法:选取笔者所在医院2020年1-12月住院及门诊收治的300例慢性阻塞性肺疾病急性加重期患者,采用随机数字表法将其分为A组、B组、C组,每组100例。A组给予安慰剂治疗,B组给予肾上腺糖皮质激素治疗,C组给予硫酸沙丁胺醇与布地奈德混悬液联合异丙托溴铵雾化吸入治疗。比较三组临床效果。结果:治疗前三组肺功能指标比较差异无统计学意义(P>0.05);治疗后,C组PEF、FEV_(1)/FVC、FEV_(1)均高于B组、A组,且B组高于A组,差异均有统计学意义(P<0.05)。治疗后,C组呼吸、6分钟步行试验距离、Borg指数均优于B组、A组,且B组优于A组,差异有统计学意义(P<0.05)。治疗前三组血气指标比较差异均无统计学意义(P>0.05);治疗后,C组PaCO_(2)、SaO_(2)、PaO_(2)均优于A组、B组,且B组优于A组,差异有统计学意义(P<0.05)。三组不良反应发生率比较差异无统计学意义(P>0.05)。结论:硫酸沙丁胺醇与布地奈德混悬液联合异丙托溴铵雾化吸入治疗慢性阻塞性肺疾病急性加重期,可改善患者肺功能、血气指标,且不良反应发生率低。

Objective:To analyze the clinical effect of Salbutamol Sulfate and Budesonide Suspension combined with Ipratropium Bromide aerosol inhalation in the treatment of acute exacerbation chronic obstructive pulmonary disease.Method:A total of 300 patients with acute exacerbation chronic obstructive pulmonary disease hospitalized and outpatients in our hospital from January to December 2020 were selected and divided into group A,group B and group C by random number table method,with 100 patients in each group.Group A was treated with placebo,group B was treated with adrenal glucocorticoid,and group C was treated with Salbutamol Sulfate and Budesonide Suspension combined with Ipratropium Bromide aerosol inhalation.The clinical effect of the three groups were compared.Result:There was no significant difference in lung function indexes between groups before treatment(P>0.05).After treatment,PEF,FEV_(1)/FVC and FEV_(1) in group C were higher than those in group B and group A,and group B was higher than group A,the differences were statistically significant(P<0.05).After treatment,respiration,6-minute walking test distance and Borg index in group C were better than those in group B and group A,and group B was better than group A,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in blood gas indexes between the three groups(P>0.05).After treatment,PaCO_(2),SaO_(2) and PaO_(2) in group C were better than those in group A and group B,and group B was better than group A,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:Salbutamol Sulfate and Budesonide Suspension combined with Ipratropium Bromide aerosol inhalation in the treatment of acute exacerbation chronic obstructive pulmonary disease can improve lung function and blood gas indexes,and the incidence of adverse reactions is low.