自噬在骨细胞中重要作用的最新研究进展:骨相关细胞活性和骨代谢

The pivotal role of autophagy in bone cells:bone-related cell activity and bone metabolism

背景:自噬对维持细胞稳态和应激敏感性有重要作用,作为细胞清除受损细胞器并实现细胞成分再循环的一种重要方式,在骨代谢中发挥着不可或缺的作用。目的:对自噬对骨髓间充质干细胞、成骨细胞、骨细胞以及破骨细胞的作用机制进行综述,以明确自噬在调节和维持骨组织细胞活性和功能等方面的意义。方法:以关键词"autophagy;bone marrow mesenchymal stem cells;osteoblasts;osteocytes;osteoclasts"计算机检索PubMed数据库与骨细胞自噬相关的研究。结果与结论:最终纳入84篇文献。发现自噬在骨代谢具有重要作用。自噬参与保持矿化和吸收的平衡,继而维持骨稳态。适当的自噬诱导剂也可能有益于骨骼重塑。自噬异常会导致骨骼平衡紊乱,导致骨质疏松等疾病。通过调节自噬维持骨稳态代谢平衡,可有助于预防或治疗骨相关疾病。

BACKGROUND:The importance of autophagy for maintaining cellular homeostasis and stress response has long been recognized.As a way for cells to selectively clear their damaged organelles to achieve the recycling of cellular components,autophagy has a pivotal role in bone metabolism.OBJECTIVE:To review the role and possible mechanisms of autophagy in regulating bone-related cell activity and function among bone marrow mesenchymal stem cells,osteoblasts,osteocytes,and osteoclasts.METHODS:PubMed was searched for studies related to autophagy using the keywords of"autophagy;bone marrow mesenchymal stem cells;osteoblasts;osteocytes;osteoclasts."RESULTS AND CONCLUSION:We finally included 84 papers.Autophagy plays an important role in bone metabolism.Autophagy is involved in maintaining the balance between mineralization and absorption,and then maintaining bone homeostasis.An appropriate autophagy inducer may also benefit bone remodeling.Abnormal autophagy can lead to disorders of bone balance,leading to diseases such as osteoporosis.We may prevent or treat bone-related diseases by regulating the level of autophagy as its function in maintaining the balance of mineralization and resorption in bone homeostasis.