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运动如何调控“肌-骨”Crosstalk分泌相关因子表达介导2型糖尿病的骨代谢 被引量:1

Mechanism of exercise improving bone metabolism in type 2 diabetics mellitus based on"Muscle-Bone"Crosstalk
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摘要 背景:2型糖尿病是因能量代谢紊乱导致的疾病。肌肉和骨骼在运动刺激条件下,通过其内分泌功能参与机体的能量代谢调控。目前,相关"肌-骨"Crosstalk介导运动调控2型糖尿病骨代谢作用机制的研究较少。目的:通过分析运动如何调控"肌-骨"Crosstalk分泌相关因子的表达水平,并作用于骨组织的病理原因,探讨基于"肌-骨"Crosstalk运动介导2型糖尿病骨代谢的作用机制。方法:检索知网(CNKI)、万方及PubMed等数据库2012年至2021年近10年的相关文献;中英文检索词为:运动,2型糖尿病,骨代谢,"肌-骨"Crosstalk,肌肉因子和exercise,type 2 diabetes mellitus,bone metabolism,"muscle-bone"Crosstalk,muscle factor。经过筛选后对纳入的50篇相关文献进行了分析探讨。结果与结论:肌肉骨骼中的生物活性因子,一部分以内分泌方式作用于骨骼,如肌肉生长抑制素(Myostatin)、骨形态发生蛋白和肌肉素等;另一部分以旁分泌方式作用于骨骼,如胰岛素样生长因子1、白细胞介素6和鸢尾素等,参与骨代谢调节,平衡骨组织中成骨细胞的骨形成和破骨细胞的骨吸收,成为运动介导肌骨系统的信使因子。运动是调控能量代谢的重要手段,其介导的内部刺激变化能够引发肌细胞和骨细胞的信号应答,激活Wnt、BMP/Smads、转化生长因子β等信号通路,从而调节肌肉骨骼系统的内分泌功能,促进代谢适应,影响2型糖尿病骨代谢。 BACKGROUND:Type 2 diabetes mellitus is a disease caused by energy metabolism disorder.Muscles and bones participate in the body’s energy metabolism regulation through their endocrine function under the condition of exercise stimulation.Currently there are few studies on the mechanism of"Muscle-Bone"Crosstalk mediated exercise regulating bone metabolism in type 2 diabetes mellitus.OBJECTIVE:By analyzing how exercise regulates the expression level of"Muscle-Bone"Crosstalk secretion-related factors and acting on the pathological reasons of bone tissue,to explore the mechanism of bone metabolism mediated by"Muscle-Bone"Crosstalk exercise in type 2 diabetes mellitus.METHODS:CNKI,WanFang,and PubMed were searched for relevant literatures published in recent 10 years.The keywords were"exercise,type 2 diabetes mellitus,bone metabolism,"Muscle-Bone"Crosstalk,muscle factor"in Chinese and English,respectively.After screening,50 eligible articles were analyzed and discussed.RESULTS AND CONCLUSION:Some of bioactive factors in muscles and bones act on the bones in an endocrine manner,such as myostatin,bone morphogenetic protein,musclin,etc.,and the others act on the bones in a paracrine manner,such as insulin-like growth factor 1,interleukin 6,irisin,etc.These factors participate in the regulation of bone metabolism,balance the bone formation of osteoblasts and bone resorption of osteoclasts in bone tissue,and become the messenger factors of exercise-mediated musculoskeletal system.Exercise is an important means to regulate energy metabolism.Exercise-mediated internal stimulus changes can trigger the signal response of muscle cells and bone cells,activate Wnt,bone morphogenetic protein/Smads,transforming growth factor-βand other signal pathways,thereby regulating the endocrine function of the musculoskeletal system,promoting metabolic adaptation and influencing bone metabolism in type 2 diabetes mellitus.
作者 曾炘瑜 陈祥和 刘波 陆鹏程 金圣杰 李文秀 田志凯 孙昌亮 Zeng Xinyu;Chen Xianghe;Liu Bo;Lu Pengcheng;Jin Shengjie;Li Wenxiu;Tian Zhikai;Sun Changliang(School of Physical Education,Yangzhou University,Yangzhou 225127,Jiangsu Province,China;School of Physical Education and Health,Hebei Normal University of Science and Technology,Qinhuangdao 066004,Hebei Province,China)
出处 《中国组织工程研究》 CAS 北大核心 2022年第2期289-295,共7页 Chinese Journal of Tissue Engineering Research
基金 中国博士后科学基金资助(2019M661957),项目负责人:陈祥和。
关键词 运动 2型糖尿病 骨代谢 “肌-骨”Crosstalk 肌肉因子 exercise type 2 diabetes mellitus bone metabolism "Muscle-Bone"Crosstalk muscle factor
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