药物警戒研究在癌症治疗领域的机遇与挑战

Opportunities and Challenges of Pharmacovigilance in Cancer Treatment

目的介绍国内外药物警戒体系和国内外癌症治疗领域药物警戒的研究进展。方法检索中国知网和PubMed建库至2021年5月31日对癌症治疗领域的药物警戒研究,进行文献综述,多角度分析其复杂因素,并归纳具目前面临的机遇和挑战。结果当前在癌症治疗中的药物警戒研究需求增加,可以利用信息技术挖掘药物与事件的潜在联系,鼓励患者参与不良反应报告,丰富信息维度,药物警戒研究将促进癌症个性化治疗方案的应用。结论现代药物警戒研究在癌症治疗领域将朝着风险预测和药品不良反应个性化管理方向发展,建立更完善的药物警戒体系有利于更好地把控患者的用药安全问题。

Objective To introduce domestic and foreign pharmacovigilance systems and review the research progress in pharmacovigilance in the field of cancer treatment at home and abroad.Methods A comprehensive research was conducted in CNKI and PubMed from inception to May 31,2021.Articles about pharmacovigilance in cancer treatment were reviewed,while the number of factors that made this sphere complicated were analyzed.Current opportunities as well as challenges were outlined.Results There was an increase in the demand for pharmacovigilance,IT could help reveal the potential connections between drugs and events,and patients’participation in adverse reaction reporting could add a new dimension to information collection,all of which could accelerate personalized cancer treatment.Conclusion Pharmacovigilance research in oncology will be oriented to risk prediction and personalized management of adverse drug reactions.The establishment of a better pharmacovigilance system is conducive to the safety of patients in drug use.