脾氨肽口服冻干粉辅助治疗肺炎支原体肺炎患儿的疗效及对血清sB7-H3及GM-CSF表达的影响

Efficacy of Spleen Aminopeptide Oral Lyophilized Powder for Mycoplasma Pneumoniae Pneumonia and Its Effects on Serum sB7-H3 and GM-CSF

目的:探讨脾氨肽口服冻干粉对肺炎支原体肺炎患儿血清可溶性B7-H3(sB7-H3)及粒细胞巨噬细胞集落刺激因子(GM-CSF)的影响。方法:选取2019年8月至2020年8月于我院就诊的支原体肺炎患儿100例,按照随机数字表法分为观察组和对照组各50例,两组患儿均给予常规治疗,对照组在常规治疗基础上给予阿奇霉素注射液,观察组则在对照组治疗基础上联合脾氨肽口服冻干粉治疗,比较两组患儿的疗效、临床症状改善情况、炎性因子水平和血清sB7-H3及GM-CSF表达情况。结果:观察组有效率为96.00%,明显高于对照组的78.00%,差异有统计学意义(P<0.05);观察组患儿发热、咳嗽、肺部啰音等临床症状消失时间及白细胞(WBC)计数恢复正常时间均显著短于对照组,差异有统计学意义(P<0.01);治疗前两组患儿肿瘤坏死因子α(TNF-α)和C反应蛋白(CRP)水平比较差异无统计学意义(P>0.05),治疗后观察组TNF-α和CRP水平明显低于对照组(P<0.01);治疗前两组患儿sB7-H3及GM-CSF水平比较差异无统计学意义(P>0.05),治疗后观察组sB7-H3及GM-CSF水平明显低于对照组(P<0.01);用药期间观察组出现头晕、心悸、转氨酶升高和胃肠道反应等不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论:脾氨肽口服冻干粉可以有效地改善肺炎支原体肺炎患儿的血清sB7-H3和GM-CSF的表达水平,降低炎症反应,恢复气道功能,改善预后,安全可靠。

Objective: To probe into the effects of spleen aminopeptide oral lyophilized powder on serum soluble B7-H3(sB7-H3) and granulocyte-macrophage colony stimulating factor(GM-CSF) in children with Mycoplasma pneumoniae pneumonia. Methods: Totally 100 children with Mycoplasma pneumoniae pneumonia admitted into our hospital from Aug. 2019 to Aug. 2020 were extracted to be divided into the observation group and the control group via the random number table, with 50 cases in each group. Both groups were given conventional treatment, the control group was treated with azithromycin injection on the basis of conventional treatment, while the observation group received spleen aminopeptide oral lyophilized powder on the basis of the control group. The efficacy, improvement of clinical symptoms, inflammatory factors and expression of serum sB7-H3 and GM-CSF were compared between two groups. Results: The effective rate of 96.00% in the observation group was significantly higher than 78.00% in the control group, with statistically significant difference(P<0.05). The disappearance time of clinical symptoms such as fever, cough and lung rales, and the recovery time of white blood cells(WBC) count in the observation group were significantly shorter than those in the control group, with statistically significant difference(P<0.01). There was no significant difference in the levels of tumor necrosis factor α(TNF-α) and C-reactive protein(CRP) between two groups before treatment(P>0.05). After treatment, the levels of TNF-α and CRP in the observation group were significantly lower than those in the control group(P<0.01). Before treatment, there was no significant difference in the levels of sB7-H3 and GM-CSF between two groups(P>0.05). After treatment, the levels of sB7-H3 and GM-CSF in the observation group were significantly lower than those in the control group(P<0.01). The incidence of adverse drug reactions such as dizziness, palpitation, elevated transaminase and gastrointestinal reactions in the observation group was not significantly different from that in the control group(P>0.05). Conclusion: Spleen aminopeptide oral lyophilized powder can effectively improve the expression levels of serum sB7-H3 and GM-CSF in children with Mycoplasma pneumoniae pneumonia, reduce the inflammatory response, restore the airway function and improve the prognosis in a safe and reliable manner.