苦酒汤预防放射性口腔黏膜炎的临床观察

Observation of the Curative Effect of Kujiu Decoction on Prevention of Radioactive Oral Mucositis

目的探讨苦酒汤预防放射性口腔黏膜炎(RTOM)的疗效。方法选取60例头颈部恶性肿瘤初次行放疗或同步放化疗的患者为研究对象,按随机数字表法分为对照组(常规干预)与观察组(常规干预+苦酒汤)各30例,比较两组RTOM发生时间、累积放疗剂量、各级RTOM发生率及唾液pH值的变化。结果观察组较对照组患者RTOM发生时间显著延长(P<0.01);累积放疗剂量提高(P<0.01);可显著降低3级RTOM发生率(P<0.01);延缓唾液pH值下降(P<0.05)。结论苦酒汤通过延缓唾液pH值下降,达到延缓和降低RTOM发生时间和严重程度,从而起到预防作用。

Objective:To investigate the effect of Kujiu Decoction on the prevention of radioactive oral mucositis.Methods:A total of 60 patients who received radiotherapy or concurrent chemoradiotherapy for the first time for head and neck malignant tumor in our hospital were selected as the research objects.According to the random number table method,they were divided into control group and observation group.The control group(30 cases,conventional intervention)and the observation group(30 cases,conventional intervention+Kujiu Decoction)were selected.The occurrence time of RTOM,cumulative radiotherapy dose,incidence of RTOM at all levels and changes in saliva pH were compared between the two groups.Results:The occurrence time of RTOM in observation group was significantly longer than that in control group(P<0.01),the cumulative radiotherapy dose was increased(P<0.01),the incidence of grade 3 RTOM was significantly decreased(P<0.01),the saliva pH decline was delayed(P<0.05).Conclusion:By delaying the decline of saliva pH value,Kujiu Decoction can reduce and improve the occurrence time and severity of radioactive oral mucositis,thus playing a preventive effect,which is worthy of further clinical application and research.