中药方剂治疗肠易激综合征用药规律分析

Analysis of the Rule of Prescription of Traditional Chinese Medicine in the Treatment of Irritable Bowel Syndrome

[目的]探讨中医药治疗肠易激综合征组方的用药规律,为中医临床用药提供依据。[方法]将中国方剂数据库中所有治疗肠易激综合征的处方录入Microsoft Excel 2019,并进行中药频数、功效、性味归经统计,采用SPSS Modeler 18.0软件,以Apriori算法进行关联规则分析;以SPSS Statistics 22.0软件进行聚类分析、因子分析。[结果]研究处方1245首,涉及460味中药,其中以甘草、白术、茯苓使用频数最高,高频中药类别以补虚药、温里药使用频数最高,药性多偏于温、平,药味以辛、甘类为主,关联规则以人参-茯苓→白术的关联度最高,聚类分析发现15组中药组合,因子分析提取出16个公因子。数据分析所得方剂多重在疏肝理气、益气健脾、温补脾肾等。[结论]肝郁脾虚、肝郁气滞、寒湿泄泻是肠易激综合征的重要病机,中医药治疗肠易激综合征以疏肝解郁、调畅气机、补脾胃之气为主要治则,最常用的中药类别为补虚药。本研究结果为肠易激综合征的临床用药提供了一定的依据。

[Objective]To investigate the rule of prescription medication in the treatment of irritable bowel syndrome(IBS),and provide the basis for clinical use of traditional Chinese medicine(TCM).[Methods]All the prescriptions for the treatment of IBS in the Chinese Prescription Database were entered into Microsoft Excel 2019 and the herb frequency,efficacy,and nature and flavor were counted.SPSS Modeler 18.0 software was used for correlation analysis with the Apriori algorithm.SPSS Statistics 22.0 software was used for clustering and factor analysis.[Results]A total of 1245 prescriptions for the treatment of IBS are studied,involving 460 kinds of TCM.Among them,Glycyrrhiza uralensis Fisch,Atractylodes macrocephala,and Poria cocos are most frequently used,and the most frequent use of high-frequency herbs are deficiency tonifying and warming herb,the properties of herb are mostly biased towards warming and calming,and flavors are mostly pungent and sweet.As for the correlation analysis rules,Panax ginseng-Poria cocos→Atractylodes macrocephala has the highest degree of association.Cluster analysis finds 15 Chinese herb combinations,16 common factors are extracted from the factor analysis.The prescriptions obtained from data analysis are multiple in soothing the liver and regulating Qi,replenishing Qi and invigorating the spleen,warming the spleen and kidney,etc.[Conclusion]Liver stagnation and spleen deficiency,liver stagnation and Qi stagnation,cold-damp diarrhea are important pathogenesis of IBS.The main therapeutic principles of TCM in treating IBS are soothing the liver and relieving depression,regulating Qi and invigorating the spleen and stomach,and the most commonly used category of herb is deficiency tonifying herbs.The results of this study provide a certain basis for clinical medication of irritable bowel syndrome.