鼠神经生长因子联合甲钴胺治疗糖尿病周围神经病对患者肌电图血脂及VitB12水平的影响

Effects of Mouse Nerve Growth Factor Combined with Mecobalamin on Electromyography Serum Lipids and VitB12 Levels in Diabetic Peripheral Neuropathy

目的:探讨鼠神经生长因子联合甲钴胺治疗糖尿病周围神经病对患者肌电图、血脂及VitB12水平的影响。方法:选取87例糖尿病周围神经病患者的临床资料进行回顾性分析,选取时间为2018年2月至2020年6月,按照治疗方法不同分为对照组(予以甲钴胺治疗,n=43)与观察组(予以鼠神经生长因子联合甲钴胺治疗,n=44),对比两组腓总神经(SNCV、MNCV)、正中神经(SNCV、MNCV)、TC、TG、HLD-L、LDL-C、NSE、VitB12及TSS评分。结果:①两组腓总神经(SNCV、MNCV)、正中神经(SNCV、MNCV)、TC、TG、LDL-C、NSE、VitB12、TSS评分的时间效应、组间效应及时间与分组的交互作用比较存在显著差异(P<0.05)。②治疗前,两组腓总神经(SNCV、MNCV)、正中神经(SNCV、MNCV)、TC、TG、LDL-C、NSE、VitB12、TSS评分比较无显著差异(P>0.05);治疗2周、4周后,观察组的腓总神经(SNCV、MNCV)、正中神经(SNCV、MNCV)、VitB12高于对照组,而TC、TG、LDL-C、NSE、TSS评分低于对照组(P<0.05)。③TC、TG、LDL-C与腓总神经、正中神经的运动神经传导速度、感觉神经传导速度呈正相关(P<0.05)。结论:鼠神经生长因子联合甲钴胺治疗DPN,既能改善神经传导速度,又能降低血脂,缓解临床症状。

Objective:To investigate the effect of rat nerve growth factor combined with methylcobalamin in the treatment of diabetic peripheral neuropathy on patients with electromyography,blood lipids and VitB12 levels.Methods:The clinical data of 87 patients with diabetic peripheral neuropathy were selected for retrospective analysis.The selection time was from February 2018 to June 2020.According to different treatment methods,they were divided into control groups(treated with mecobalamin,n=43)and Observation group(treated with mouse nerve growth factor combined with mecobalamin,n=44),compare the two groups of common peroneal nerve(SNCV,MNCV),median nerve(SNCV,MNCV),TC,TG,HLD-L,LDL-C,NSE,VitB12 and TSS scores.Results:①the two groups of common peroneal nerve(SNCV,MNCV),median nerve(SNCV,MNCV),TC,TG,LDL-C,NSE,VitB12,TSS score time effect,group effect and time and grouping There is a significant difference in the interaction of the two(P<0.05).②there was no significant difference in the scores of common peroneal nerve(SNCV,MNCV),median nerve(SNCV,MNCV),TC,TG,LDL-C,NSE,VitB12,and TSS before treatment(P>0.05).After 2 weeks and 4 weeks of treatment,the common peroneal nerve(SNCV,MNCV),median nerve(SNCV,MNCV),and VitB12 of the observation group were higher than those of the control group,while the scores of TC,TG,LDL-C,NSE and TSS were lower Control group(P<0.05).③TC,TG,LDL-C were positively correlated with the motor nerve conduction velocity of the common peroneal nerve and the median nerve,and the sensory nerve conduction velocity(P<0.05).Conclusion:The combination of mouse nerve growth factor and methylcobalamin in the treatment of DPN can not only improve nerve conduction velocity,but also reduce blood lipids and relieve clinical symptoms.