哮喘患儿血清Eotaxin水平与肺功能Eos及sIgE的关系分析

An Analysis of the Relationship Between Serum Eotaxin Level and Lung Function Eos and SIgE in Children with Asthma

目的:探索哮喘患儿血清Eotaxin水平与肺功能、Eos及sIgE的关系。方法:回顾性分析在2018年2月至2020年9月期间收集的65例健康体检者(对照组)、67例哮喘患儿(观察组)基本资料,均进行肺功能、Eotaxin、Eos、sIgE检测,对比两组小儿上述指标,运用Pearson法分析,Eotaxin分别与Eos、sIgE、肺功能相关性。结果:观察组PEF、FEV1、FVC低于对照组,Eotaxin、Eos、sIgE高于对照组(P<0.05)。经Pearson法分析,Eotaxin与Eos、sIgE呈正相关性;与PEF、FEVI、FVC呈负相关性。多元逐步回归分析显示,Eos、sIgE、FEVI均为Eotaxin影响因素,且Eotaxin=17.791+4.169×Eos+0.779×sIgE+(-5.711)×FEVI(R2=0.974)。结论:Eotaxin与Eos、sIgE及肺功能存在密切关系,参与了哮喘小儿的病理生理过程。

Objective:To explore the relationship between serum Eotaxin level and lung function,Eos and sIgE in children with asthma.Methods:A retrospective analysis of the basic data of 65 healthy subjects(control group)and 67 children with asthma(observation group)collected from February 2018 to September 2020 were all tested for lung function,Eotaxin,Eos,and sIgE.The above indicators between the two groups of children were compared,and Pearson's method was conducted to analyze the correlation between Eotaxin and Eos,sIgE,and lung function.Results:PEF,FEV1 and FVC in the observation group were lower than those in the control group,while Eotaxin,Eos and sIgE were higher than those in the control group(P<0.05).According to Pearson method,Eotaxin is positively correlated with Eos and sIgE;it is negatively correlated with PEF,FEVI,and FVC.Multiple stepwise regression analysis showed that Eos,sIgE,and FEVI are all Eotaxin influencing factors,and Eotaxin=17.791+4.169×Eos+0.779×sIgE+(-5.711)×FEVI(R2=0.974).Conclusion:Eotaxin is closely related to Eos,sIgE and lung function,and participates in the pathophysiological process of children with asthma.