聚乙二醇与玻璃酸钠滴眼液治疗白内障术后眼干燥症的效果和对患者泪液炎症介质的影响

Effect of polyethylene glycol eye drops and sodium hyaluronate in the treatment of Xerophthalmia after cataract surgery and the influence on tear inflammatory factors

目的探讨聚乙二醇与玻璃酸钠滴眼液治疗白内障术后眼干燥症的效果和对患者泪液炎症介质的影响。方法选取2018年3月至2020年3月于营口经济技术开发区中心医院行白内障手术后出现眼干燥症的86例患者作为研究对象,使用信封法将其随机分为对照组与观察组,每组43例。对照组予以聚乙二醇滴眼液治疗,观察组予以玻璃酸钠滴眼液治疗。比较两组眼干燥症症状评分、泪膜破裂时间(BUT)以及泪液炎症介质[白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]水平。结果术后,两组眼干燥症症状评分及BUT比较差异无统计学意义(P>0.05);术后1个月,观察组眼干燥症症状评分明显低于对照组,BUT显著长于对照组,差异有统计学意义(P<0.05)。术前,两组IL-1β、IL-8、TNF-α水平比较差异无统计学意义(P>0.05);术后1个月,观察组泪液IL-1β、IL-8、TNF-α水平明显低于对照组(P<0.05)。结论玻璃酸钠滴眼液可以有效减轻白内障术后眼干燥症患者的不良症状,同时促进泪膜稳定,减轻眼部炎症程度。

Objective To explore the effect of polyethylene glycol eye drops and sodium hyaluronate in the treatment of xerophthalmia after cataract surgery and the influence on tear inflammatory factors. Methods 86 patients with xerophthalmia after cataract surgery in our hospital from March 2018 to March 2020 were selected and randomly divided into two groups: the control group(treated with polyethylene glycol eye drops) and the observation group(treated with sodium hyaluronate), with 43 cases in each group.The symptom score, break time(but) and levels of tear inflammatory factors(IL-1β, IL-8, TNF-α) were compared between the two groups. Results After operation, there was no significant difference in xerophthalmia symptom score and but between the two groups(P>0.05);one month after operation, the xerophthalmia symptom score of the observation group was significantly lower than that of the control group, but was also longer(P<0.05). Before operation, there was no significant difference in tear inflammatory factor levels between the two groups(P>0.05);one month after operation, the levels of tear IL-1β, IL-8 and TNF-α in the observation group were significantly lower than those in the control group(P<0.05). Conclusion Sodium hyaluronate eye drops can effectively reduce the adverse symptoms of patients with xerophthalmia after cataract surgery, promote tear film stability, and reduce the degree of eye inflammation.