姜黄素通过增加抗氧化能力来减弱运动诱导的氧化应激

Curcumin Attenuates Exercise-induced Oxidative Stress by Increasing Antioxidant Capacity

为了探讨姜黄素对人体运动诱导氧化应激的影响,本研究选择30名男性受试者进行研究,所有受试者按随机顺序完成3项试验:(1)安慰剂组(Control)、(2)单姜黄素组(仅在运动前, Single)和(3)双姜黄素组(运动前和运动后,Double)。受试者在运动前2h和运动后立即口服100mg姜黄素或安慰剂。受试者在跑步机上以65%的VO2max跑步60 min。在运动前、运动后和运动2 h后收集血样检测氧化应激和抗氧化活性指标。研究显示,摄入姜黄素的受试者运动后的血清d-ROM浓度和血浆TRX-1浓度显著低于运动前(P<0.05)。运动后,摄入姜黄素的受试者的血清BAP浓度显著高于运动前(P<0.05)。运动2 h后,单次摄入姜黄素的受试者的血浆GSH浓度显著高于运动前(P<0.05)。本研究结果表明摄入姜黄素可以通过增加人体的抗氧化能力来减弱运动诱导的氧化应激。

In order to investigate the effect of curcumin on human exercise-induced oxidative stress. In this study,30 male subjects were selected for the study, and all subjects completed 3 trials in random order:(1) placebo group(Control),(2) single curcumin group(only before exercise, Single) and(3) double curcumin group(before and after exercise, Double). Subjects received 100 mg of curcumin or placebo 2 hours before exercise and immediately after exercise. Subjects ran for 60 min on a treadmill with 65% VO2 Max. Blood samples were collected before exercise, after exercise, and after 2 hours of exercise to detect oxidative stress and antioxidant activity indicators.Studies have shown that serum d-ROMs concentrations and plasma TRX-1 concentrations after exercise were significantly lower than that of before exercise in subjects who received curcumin(P<0.05). After exercise, serum BAP concentrations in subjects who received curcumin were significantly higher than that of before exercise(P<0.05). After 2 hours of exercise, the plasma GSH concentration of subjects who received curcumin for a single time was significantly higher than that of before exercise(P<0.05). The results showed that the intake of curcumin can attenuate exercise-induced oxidative stress by increasing the body’s antioxidant capacity.