楝酰胺类化合物的抗肿瘤活性探究进展

Research Progress in Antitumor Activity of Rocaglamide Analogues

楝酰胺类化合物存在于楝属植物中,因其独特的化学结构而具有杀虫、抗炎及抗癌的活性。目前研究发现,楝酰胺类化合物对多种癌症如肺癌、肾癌、胰腺癌、恶性外周神经鞘瘤等都具有独特的细胞凋亡作用,而对正常细胞无毒害作用。楝酰胺类化合物抗肿瘤的机制主要有:抑制癌细胞翻译起始、调控细胞周期、诱导肿瘤细胞凋亡、抑制细胞增殖、降低药物细胞毒性等。因此,楝酰胺及其衍生物作为潜在抗癌药物也有极大的应用前景,成为近年来的研究热点。本综述总结了楝属植物中的次生代谢产物-楝酰胺类化合物的发现过程、结构特征和抗癌活性,重点阐述了其在癌症中的作用机制。以期为楝酰胺类化合物的进一步研究和开发利用提供理论依据和研究思路,并对楝酰胺类化合物的应用前景进行了展望。

Rocaglamide and its analogues are extracted from the genus of Melia L. Most of them have insecticidal,anti-inflammatory and anticancer activities due to their unique chemical structure. At present, it has been found that rocaglamides have the effect of inducing apoptosis in lung cancer, renal cell carcinoma, pancreatic cancer, and malignant peripheral nerve sheath tumor, but have no toxic effects on normal cells. The anti-tumor mechanism of rocaglamides mainly includes: inhibiting the initiation of translation of cancer cells, regulating cell cycle, inducing apoptosis of tumor cells, inhibiting cell proliferation, and reducing drug cytotoxicity. Therefore, rocaglamide and its analogues as potential anticancer drugs have shown great application potential, and relative researches have been paid more attentions in recent years. In this review, the discovery progress, structural characteristics, anticancer activity and mechanisms of activity in cancer involved in the secondary metabolite of plants of the genus of Melia L. were summarized. In order to provide theoretical basis and research ideas for the further research and development of rocaglamides, the application prospects of rocaglamides were prospected.