雷珠单抗用药后玻璃体切除时机对增生性糖尿病视网膜病变疗效的影响

Effect of the timing of vitrectomy after ranibizumab administration on the curative effect of proliferative diabetic retinopathy

目的分析雷珠单抗用药后玻璃体切除时机对增生性糖尿病视网膜病变(PDR)疗效的影响。方法选取2018年1月~2020年6月住院治疗的54例PDR患者,以随机抽样法分组,甲组18例患者在雷珠单抗注射3~6 d后接受玻璃体切除手术治疗,乙组18例患者在雷珠单抗注射7~10 d后接受玻璃体切除手术治疗,丙组18例患者在雷珠单抗注射11~15 d后接受玻璃体切除手术治疗,对比三组临床疗效、黄斑中心凹厚度(CFT)、最佳矫正视力(BCVA)、并发症发生率。结果①乙组总有效率(94.44%)高于甲组(55.56%)、丙组(61.11%),差异均具有统计学意义(P<0.05),甲组临床总有效率与丙组比较无显著差异(P>0.05)。②术后,乙组CFT、BCVA均低于甲组、丙组,差异均具有统计学意义(P<0.05),甲组CFT、BCVA与丙组比较无显著差异(P>0.05)。③乙组并发症发生率(0.00%)低于甲组(27.78%)、丙组(33.33%),差异均具有统计学意义(P<0.05),甲组并发症发生率与丙组比较无显著差异(P>0.05)。结论雷珠单抗注射7~10 d后接受玻璃体切除手术治疗PDR总有效率较高,可有效矫正患者视力,且并发症较少。

Objective To investigate the effect of the timing of vitrectomy after ranibizumab administration on the curative effect of proliferative diabetic retinopathy.Methods 54 patients with PDR who were hospitalized in our hospital from January 2018 to June 2020 were selected and grouped by random sampling.18 patients in group A underwent vitrectomy for 3 to 6 days after ranibizumab injection,and 18 patients in group B patients in group C received vitrectomy surgery for 7 to 10 days after ranibizumab injection,and 18 patients in group C received vitrectomy surgery after 11~15 days ranibizumab injection.The clinical efficacy,CFT,BCVA,and complications of the three groups were compared.Results①The total effective rate of group B(94.44%)is higher than that of group A(55.56%)and group C(61.11%),and the difference is statistically significant(P<0.05).The total clinical effective rate between group A and group C has no significant difference(P>0.05).②After operation,the CFT and BCVA of group B were lower than those of group A and group C,and the difference was statistically significant(P<0.05).There was no significant difference between group A and group C in CFT and BCVA(P>0.05).③The complication rate of group B(0.00%)was lower than that of group A(27.78%)and group C(33.33%),and the difference was statistically significant(P<0.05).The complication rate of group A was lower than that of group C,but there was no significant difference(P>0.05).Conclusion After 7~10 days of ranibizumab injection,vitrectomy for PDR has a higher overall effective rate,which can effectively correct the patient's vision with fewer complications.