植物病原真菌的自噬

Research progress on autophagy of plant pathogenic fungi

作为真核生物中普遍存在的现象,自噬不但实现了对细胞内物质的降解和回收利用,而且与植物病原真菌早期侵染阶段的附着胞发育、膨压升高、菌丝体形成、完成侵染等一系列过程密切相关,并且发挥了重要的作用。本文归纳了植物病原真菌自噬的相关基因和自噬过程;总结了自噬对病原真菌生长发育、致病力的调控和影响;概括了病原真菌自噬所涉及的信号通路;阐明了自噬影响植物病原真菌侵染过程的主要分子机制。为今后以自噬相关基因或蛋白作为靶点来筛选抑制病原真菌侵染的新型药物提供新的策略和思路。

As a ubiquitous phenomenon in eukaryotes,autophagy not only achieves the degradation and recycling of intracellular substances,but also interacts with a series of processes such as the appressorium development,turgor increase,mycelium formation,and completion of infection,etc,in the early infection stage of plant pathogenic fungi,and plays an important role in these bio-processes.In the present review the autophagy related genes and the autophagy process of phytopathogenic fungi are smmarized;the regulation and influence of autophagy on the growth and development and the pathogenicity of pathogenic fungi are generalized;the autophagy related signaling pathways of pathogenic fungi are illustrated;and the main molecular mechanisms of autophagy influencing the infection processes of phytopathogenic fungi are clarified.These provide new strategies and ideas for screening new drugs that inhibit pathogenic fungi infection by using autophagy-related genes or proteins as targets in future studies.