LncRNA TUG1在肝癌中的研究进展

Research progress of lncRNA TUG1 in liver cancer

肝细胞癌(hepatocellular carcinoma,HCC)是我国最常见且死亡率最高的恶性肿瘤之一。由于目前缺乏灵敏的早期诊断指标,许多患者发现时已是晚期,导致预后不佳,5年生存率低。因此,找到相应的肿瘤标记物将有助于早期肝癌的诊断。近些年的研究发现,牛磺酸上调基因1(taurine upregulated gene 1,TUG1)在肝癌中的表达明显上调,与肝癌的发生、发展以及预后都密切相关。同时,进一步研究发现,下调TUG1可以降低肝癌细胞的侵袭、转移、增殖等能力,还可以促进细胞的凋亡。TUG1在肿瘤的早期诊断、疗效判断及预后评估等方面具有重要的潜在价值。该文将重点介绍TUG1作为癌基因在HCC中发挥的功能和作用机制,以及它作为HCC诊断和治疗的潜在靶点的可能性。

Hepatocellular carcinoma(HCC)is a frequently observed cancer with the highest mortality in China.At present,there is a lack of accurate early diagnosis indicators for HCC,and most patients have already progressed to advanced stages at diagnosis,resulting in poor prognosis and a low 5-year survival rate.Therefore,the idenfication of corresponding indicators would assist in the early diagnosis of liver cancers.Recent studies have shown that the expression of taurine upregulated gene 1(TUG1)is significantly upregulated in hepatocellular carcinoma and is closely related to the development,progression and prognosis of hepatocellular carcinoma.At the same time,further studies have found that down-regulation of TUG1 can not only reduce the invasion,metastasis and proliferation of hepatocellular carcinoma cells,but also promote apoptosis.TUG1 is of great potential value in the early diagnosis,efficacy evaluation and prognosis prediction for tumor patients.This article will focus on the function and mechanism of action of TUG1 as an oncogene in HCC,and its potential as a target for HCC diagnosis and treatment.