致命鹅膏中毒三例报道

Three cases of mushroom poisoning caused by lethal Amanita species

含鹅膏肽类毒素致命鹅膏中毒可导致患者肝功能障碍,严重者出现死亡,经酶联免疫吸附测定法(ELISA)检测鹅膏肽类毒素有助于早期临床确诊。本文三例患者经ELISA鉴定为含α-鹅膏毒肽的致命鹅膏中毒,中毒患者以消化系统损害为首发症状,后期出现肝功能损害,1例患者放弃治疗后死亡,予以吸附毒素、导泻、补液促进毒物代谢、保肝等支持治疗后,2例患者好转出院。

Mushroom poisoning with amatoxins can cause liver dysfunction in patients,and death in severe cases.The amatoxins detection by enzyme-linked immunosorbent assay(ELISA)can help early clinical diagnosis.Three patients were identified asα-amatoxin containing mushroom poisoning by ELISA.The first symptoms of patients was gastrointestinal symptoms,and liver function damage occured later.One patient gave up treatment and died.After received supportive treatments such as adsorption of toxins,catharsis,fluid supplementation to promote toxin metabolism and liver protection,2 patients were recovered and discharged.