丹参酮胶囊联合常规西医治疗寻常型痤疮的疗效分析

Effect of tanshinone capsule combined with conventional western medicine on acne vulgaris

目的研究丹参酮胶囊联合异维A酸软胶囊、克拉霉素片治疗寻常型痤疮的疗效,为临床提供参考。方法采用随机数字表法将2019年1月—2020年12月于中国人民解放军联勤保障部队第904医院治疗的137例寻常型痤疮分为对照组(68例,异维A酸软胶囊、克拉霉素片)和研究组(69例,丹参酮胶囊联合异维A酸软胶囊、克拉霉素片),比较2组患者疗效、安全性以及治疗前后皮损积分、炎性因子及体液免疫指标。结果研究组临床总有效率(82.61%)高于对照组(66.18%,P<0.05)。研究组治疗后IgG[(8.12±1.28)g/L vs.(12.08±1.29)g/L]、IL-4[(19.13±2.39)ng/L vs.(25.67±3.36)ng/L]、IL-17[(1.98±0.33)ng/L vs.(2.47±0.41)ng/L]、TNF-α[(28.67±4.52)ng/L vs.(36.28±5.46)ng/L]以及皮损积分脓疱[(1.51±0.35)分vs.(1.89±0.46)分]、丘疹[(1.34±0.22)分vs.(1.73±0.41)分]、粉刺[(1.31±0.28)分vs.(1.79±0.32)分]、结节囊肿[(1.24±0.26)分vs.(1.69±0.22)分]均低于对照组(均P<0.05),2组不良反应发生率比较差异无统计学意义。结论丹参酮胶囊联合异维A酸软胶囊、克拉霉素片可有效治疗寻常型痤疮,降低患者炎性因子,一定程度上改善免疫功能。

Objective To explore the clinical effect of tanshinone capsule combined with isotretinoin soft capsule and clarithromycin tablets in the treatment of acne vulgaris.Methods A total of 137 cases of acne vulgaris treated in the 904 th Hospital of PLA Joint Logistics Support Force from January 2019 to December 2020 were selected and randomly divided into control group(n=68,isotretinoin soft capsule and clarithromycin tablets)and study group(n=69,tanshinone capsule combined with isotretinoin soft capsule and clarithromycin tablets).The curative effect,security and the skin lesion score,inflammatory factors and humoral immune indexes were compared before and after treatment between both groups.Results The total effective rate of the study group(82.61%)was higher than that of the control group(66.18%,P<0.05).After treatment,the IgG[(8.12±1.28)g/L vs.(12.08±1.29)g/L],IL-4[(19.13±2.39)ng/L vs.(25.67±3.36)ng/L],IL-17[(1.98±0.33)ng/L vs.(2.47±0.41)ng/L],TNF-α[(28.67±4.52)ng/L vs.(36.28±5.46)ng/L]and the scores of pustules[(1.51±0.35)points vs.(1.89±0.46)points],papules[(1.34±0.22)points vs.(1.73±0.41)points],acne[(1.31±0.28)points vs.(1.79±0.32)points],nodules and cysts[(1.24±0.26)points vs.(1.69±0.22)points]were lower than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Tanshinone capsule combined with isotretinoin soft capsule and clarithromycin tablets can effectively treat acne vulgaris,and improve the immune function to a certain extent.