全身麻醉药物引起髓鞘发育毒性和精细运动损伤的研究进展

Research advances in the mechanism of general anesthetics induced myelination deficits and fine motor impairment

国内每年有超出数百万的婴幼儿在全身麻醉下接受外科手术,而婴幼儿此时正处于神经发育关键期,全身麻醉药物刺激可能会对快速发育中的大脑结构功能产生影响。文章概括了最新的研究全身麻醉影响患儿远期神经行为学功能的临床试验结果,同时将基础研究中全身麻醉药物可能存在与临床上神经行为学改变密切相关的毒理机制进行了总结,为全身麻醉药物更加合理、安全地运用于婴幼儿提供临床参考。

Over millions of infants in our country have surgery under general anesthesia every year.However,general anesthetics may bring about some structure and functional changes in the rapidly developmental brain of infants,which is in the crucial stage of neural development.This review summarizes the latest advances of the latest clinical trials about the effects of general anesthesia on long-term neuropsychological deficits of infants,and the underlying mechanisms of neurotoxicity from basic research,which is closely related to the results of clinical research.Nevertheless,the mechanism needs further research to provide a safer and more reasonable guidance in the administration of general anesthetics to infants.