山东省2014—2016年新诊断HIV/AIDS随访情况及与治疗的关联分析

Follow-up status and its correlation with HAART in newly diagnosed HIV/AIDS patients from 2014 to 2016 in Shandong province

目的分析山东省新诊断HIV/AIDS接受随访情况及与治疗的关系,为提高随访治疗质量提供理论依据。方法采用回顾性队列研究,运用logistic回归模型进行影响因素分析,利用χ2检验分析随访与治疗的关联。结果2014—2016年山东省新诊断HIV/AIDS共6253例,其中6011例接受随访,累积随访率96.13%,及时随访率94.51%。15~24岁、咨询检测发现、大专及以上学历、居住地在鲁东地区及经同性性行为感染的HIV/AIDS累积随访率和及时随访率均较高,及时接受随访的HIV/AIDS的治疗率是不及时者的5.28倍(OR=5.28,95%CI:3.51~7.95),病毒载量(VL)抑制率是其4.30倍(OR=4.30,95%CI:2.89-6.40)。结论HIV/AIDS随访及时性与其诊断基线年龄、样本来源、文化程度、居住地区及传播途径有关联。及时随访可提高HIV/AIDS治疗率及治疗效果。

Objective To analyze the status of follow-up and its correlation with highly active antiretroviral therapy(HAART)for newly diagnosed HIV/AIDS patients from 2014 to 2016 in Shandong province,then to provide theoretical evidence for the improvement of follow-up and HAART.Methods Based on retrospective cohort study,logistic regression model was used to identify influencing factors of follow-up for HIV/AIDS,and chi-square test was used to do correlation analysis.Results There were 6253 newly diagnosed HIV/AIDS cases from 2014 to 2016 in Shandong province,and 6011 cases accepted follow-up service.The cumulative follow-up rate was 96.13%,and timely follow-up rate was 94.51%.Higher prevalence of follow-up was found among those aged 15-24 years at diagnosis,diagnosed by VCT,with education level of college and above,lived in east of Shandong province and infected with homosexual sex behaviors.HIV/AIDS cases who received follow-up service within 1 year of diagnosis were more likely to receive HAART(OR=5.28,95%CI:3.51-7.95)and meet the level of viral load(VL)suppression(OR=4.30,95%CI:2.89-6.40)than those who received follow-up service later.Conclusions The status of follow-up of HIV/AIDS in Shandong province was influenced by age at diagnosis,sample resource,cultural level,address and transmission route.Timely follow-up can improve the proportion and effect of HIV/AIDS treatment.