小儿急性巨核细胞白血病1例

A case of acute megakaryocytic leukemia in children

目的本文确诊1例罕见的小儿急性巨核细胞白血病病例,分析其临床及细胞形态学特征,以期提高对巨核细胞白血病的认识,减少误诊及漏诊的发生。方法收集2017年5月外院转诊小儿急性白血病病例1例,完善骨髓和外周血细胞形态学检查及其他相关检查。结果骨髓与外周血细胞形态结果一致,诊断意见为考虑AML-M7-BM象。骨髓流式细胞免疫分型提示AML-M7肿瘤细胞来源,AML-M7诊断成立。结论本例小儿白血病证实为急性巨核细胞白血病,临床罕见。细胞形态学检查、免疫组化、电镜PPO、流式细胞仪等检查相结合对该疾病诊断及治疗有重要意义。

Objective A rare case of acute megakaryocytic leukemia in children was confirmed,and the clinical and cellular morphological characteristics were analyzed in order to improve the understanding of megakaryocytic leukemia and reduce the misdiagnosis and missed diagnosis.Methods A case of pediatric acute leukemia referred to another hospital in May 2017 was collected,and the morphological examination of bone marrow and peripheral blood cells and other related examinations were completed.Results The results of bone marrow and peripheral blood cell morphology were consistent,and the diagnosis showed that AML-M7-BM image was considered.Bone marrow flow cytometric immunotyping indicated the origin of AML-M7 tumor cells,and the diagnosis of AML-M7 was confirmed.Conclusion This case of pediatric leukemia was proved to be acute megakaryocytic leukemia,which is clinically rare.The combination of morphological examination,immunohistochemistry,PPO and flow cytometry is of great significance for the diagnosis and treatment of this disease.