益血生胶囊治疗儿童急性白血病化疗后骨髓抑制临床研究

Clinical Study on Yixuesheng Capsule in the Treatment of Myelosuppression in Children with Acute Leukemia after Chemotherapy

目的探讨益血生胶囊对儿童急性白血病化疗后骨髓抑制的临床效果。方法选择70例儿童急性白血病化疗后骨髓抑制患者,按随机数字表法分为2组,每组35例。对照组给予重组人粒细胞集落因子治疗,观察组在对照组治疗基础上,给予益血生胶囊。比较2组骨髓抑制症状减轻的时间、住院时间、治疗前后患儿白细胞计数、血小板计数、血红蛋白、T细胞亚群监测指标、总有效率、复发率。结果观察组骨髓抑制症状减轻时间、住院时间短于对照组,差异有统计学意义(P<0.05)。治疗前,2组患儿白细胞计数、血小板计数、血红蛋白值、T细胞亚群监测指标比较,差异无统计学意义(P>0.05);治疗后,2组患儿白细胞计数、血小板计数、血红蛋白值均较本组治疗前降低,CD^(4+)、CD^(8+)、CD^(4+)/CD^(8+)均较本组治疗前升高,差异有统计学意义(P<0.05);治疗后观察组和对照组的上述指标比较,差异有统计学意义(P<0.05),说明治疗后观察组白细胞计数、血小板计数、血红蛋白值下降幅度小,骨髓抑制得到改善,观察组CD^(4+)、CD^(8+)、CD^(4+)/CD^(8+)值升高幅度大,免疫系统激活更佳。观察组复发率2.86%(1/35)低于对照组5.71%(2/35),差异无统计学意义(P>0.05)。结论益血生胶囊对于儿童急性白血病化疗后骨髓抑制的治疗效果确切,可有效改善患儿骨髓抑制的症状,减轻血象降低的情况,改善免疫功能,并缩短住院时间,值得推广。

Objective to analyze the clinical effect of Yixuesheng capsule on myelosuppression in children with acute leukemia after chemotherapy.Methods A total of 70 patients with myelosuppression in children with acute leukemia after chemotherapy in the First Affiliated Hospital of Gannan Medical University were randomly divided into two groups:control group(n=35)and observation group(n=35).The patients in the control group were treated with recombinant human granulocyte colony factor,and the observation group was treated with Yixuesheng capsule.The time of relief of myelosuppression symptoms,length of hospital stay,white blood cell count,platelet count,hemoglobin,T cell subgroup monitoring index,total effective rate and recurrence rate was compared between the two groups.Results The time to relieve symptoms of bone marrow suppression and hospital stay in the observation group were shorter than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference between the observation group and the control group in white blood cell count,platelet count,hemoglobin,and T cell subset monitoring indicators(P>0.05).After treatment,the white blood cell count,platelet count,and hemoglobin of the observation group and the control group decreased,and CD^(4+),CD^(8+),CD^(4+)/CD^(8+)increased,and the difference was statistically significant(P<0.05);after treatment,the observation group and the control group had the above Compared with the indicators,the difference was statistically significant(P<0.05).After treatment,the total effective rate of the observation group was 94.29%(33/35)higher than that of the control group 74.29%(26/35),and the difference was statistically significant(P<0.05).The recurrence rate of the observation group was 2.86%(1/35)lower than that of the control group 5.71%(2/35),and the difference was not statistically significant(P>0.05).Conclusion Yixuesheng capsule is effective in the treatment of myelosuppression in children with acute leukemia after chemotherapy,which can effectively improve the symptoms of myelosuppression,reduce the decrease of hemogram,improve immune function and shorten the time of hospitalization,which is worth popularizing.