摘要
靶向治疗、放疗、免疫疗法以及手术等癌症治疗方法的最新进展使肿瘤患者病情得到了良好改善,患者生存期也得以延长。尽管肿瘤治疗取得了这些进展,但引入的靶向药物所致肾毒性作用给临床增加了新的挑战,抗肿瘤药的肾毒性作用已经成为限制肿瘤治疗疗效的一个日益重要的因素。肿瘤肾脏病学领域正在迅速扩大和发展,密切的合作及对这两个领域充分的熟悉是非常必要的。本文对各种传统化疗药、靶向药和免疫治疗所致肾毒性及其防治进行综述,以期为临床治疗提供新思路。
Recent advances in cancer treatment methods such as targeted therapy,radiotherapy,immunotherapy and surgery have improved tumor control and prolonged the survival time in patients with tumor.Despite these advances in tumor therapy,the introduction of nephrotoxic effects caused by the targeted drugs have added new challenges to the clinic,and the nephrotoxic effects of antineoplastic have become an increasingly important factor limiting the efficacy of tumor therapy.The field of oncology nephrology is rapidly expanding and developing,close cooperation and adequate familiarity with both areas are therefore essential.This paper summarized the prevention and nephrotoxicity caused by various traditional chemotherapeutics,targeted drugs and immunotherapy,in order to provide new ideas for clinical diagnosis and treatment.
作者
刘水英
王锋
汪年松
LIU Shuiying;WANG Feng;WANG Niansong(Department of Nephrology,Shanghai Eighth People’s Hospital Affiliated to Jiangsu University,Shanghai 200233,China;Department of Nephrology,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai 200233,China)
出处
《世界临床药物》
2021年第10期838-844,共7页
World Clinical Drug
基金
国家自然基金面上项目(81770741、81870504)。
关键词
抗肿瘤药
急性肾损伤
预防
治疗
antineoplastic
acute kidney injury
prevention
treatment
