山蜡梅叶颗粒联合克拉霉素治疗慢性咽炎的临床疗效

Effect of Shanlameiye granule combined with clarithromycin in the treatment of chronic pharyngitis

目的:观察山蜡梅叶颗粒联合克拉霉素治疗慢性咽炎的效果。方法:前瞻性选取2018年1月—2020年1月于本院门诊接受药物治疗的86例慢性咽炎患者作为研究对象,随机数表法分为对照组和观察组各43例。对照组口服克拉霉素缓释片0.5 g/次,1次/d,于餐中服用;观察组在对照组基础上服用山蜡梅叶颗粒,10 g/次,开水冲服,3次/d。两组均连续治疗2周。于治疗2周评估疗效,记录患者中医证候积分,检测炎症及免疫指标水平,记录不良反应。结果:观察组治疗总有效率高于对照组(P<0.05)。两组治疗前中医证候各项积分比较,差异无统计学意义(P>0.05);两组治疗2周中医证候各项积分较治疗前降低,且观察组低于对照组(P<0.05)。两组治疗前TNF-α和IL-2水平比较,差异无统计学意义(P>0.05);两组治疗2周TNF-α水平较治疗前降低,IL-2水平较治疗前升高,且观察组TNF-α水平低于对照组,IL-2水平高于对照组(P<0.05)。观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论:山蜡梅叶颗粒联合克拉霉素治疗慢性咽炎疗效确切,可减轻患者证候,改善炎症及免疫指标,且联合治疗方案有一定安全性。

Objective:To observe the effect of Shanlameiye granule combined with clarithromycin in treating chronic pharyngitis.Methods:86 patients with chronic pharyngitis who received drug therapy in the outpatient of our hospital from January 2018 to January 2020 were prospectively selected as the research subjects.They were divided by a random number table method into a control group and an observation group with 43 cases in each group.The control group took clarithromycin sustained-release tablets by 0.5 g/time,once a day,and took the drug in meals.On the basis of the control group,the observation group was given Shanlameiye granule by 10 g/time,three times per day.Both groups were treated for two weeks.After two weeks of treatment,the curative effect was evaluated.The TCM syndrome scores of patients,the levels of inflammation and immune indexes,and the adverse reactions were recorded.Results:Compared with the control group,the total effective rate of the observation group was higher(P<0.05).There was no statistically significant difference in the scores and total scores of TCM syndromes between the two groups before treatment(P>0.05).The scores and total scores of TCM syndromes in both groups were lower than those before treatment,and the scores in the observation group were lower than that in the control group(P<0.05).In addition,there was no statistically significant difference in the levels of TNF-αand IL-2 between the two groups before treatment(P>0.05).After two weeks of treatment,the level of TNF-αwas decreased,and the level of IL-2 was increased in both groups than those before treatment.The level of TNF-αwas lower,while the level of IL-2 in the observation group was higher than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between both groups(P>0.05).Conclusion:Shanlameiye granule combined with clarithromycin is effective in treating chronic pharyngitis,which can reduce the symptoms of patients,improve the inflammatory and immune indicators,and the combined treatment regimen is safe.